Results 21 to 30 of about 13,221 (182)
Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease
Frontiers in Molecular Biosciences, 2020 Several neurological disorders have been linked to mutations in chaperonin genes and more specifically to the HSPD1 gene. In humans, HSPD1 encodes the mitochondrial Heat Shock Protein 60 (mtHsp60) chaperonin, which carries out essential protein folding ...
Alejandro Rodriguez +3 more
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Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells. [PDF]
PLoS ONE, 2014 To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear.
So Jung Park +11 more
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The Journal of Clinical Investigation, 2022 Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar +14 more
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Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics
Frontiers in Molecular Biosciences, 2018 The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin protein working together with co-chaperonin 10 kDa heat shock protein (Hsp10).
Qianli Meng +2 more
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GroEL Chaperonin-Based Assay for Early Diagnosis of Scrub Typhus
Diagnostics, 2022 A point-of-care diagnostic for early and rapid diagnosis of scrub typhus caused by Orientia tsutsugamushi is required for prompt and proper treatment of patients presenting with undifferentiated febrile illnesses.
Nitaya Indrawattana +7 more
doaj +1 more source
Potential marker proteins for ozone-induced yield reduction in rice
Advances in Horticultural Science, 2018 Three proteins - a 60-kDa chaperonin (CPN-60), chloroplastic ATP synthase, and enolase 1 - were evaluated as potential markers of ozone-induced yield responses in six rice (Oryza sativa L.) cultivars (‘Kirara 397’, ‘Koshihikari’, ‘Nipponbare’, ‘Takanari’,
H. Sawada +3 more
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Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer. [PDF]
PLoS ONE, 2014 Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with
Xiao-shan Li +3 more
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Root exudate-induced alterations in Bacillus cereus cell wall contribute to root colonization and plant growth promotion. [PDF]
PLoS ONE, 2013 The outcome of an interaction between plant growth promoting rhizobacteria and plants may depend on the chemical composition of root exudates (REs). We report the colonization of tobacco, and not groundnut, roots by a non-rhizospheric Bacillus cereus ...
Swarnalee Dutta +2 more
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Expression of plant chaperonin-60 genes in Escherichia coli
Journal of Biological Chemistry, 1992 We have examined the expression in Escherichia coli of genes encoding a plant chloroplast molecular chaperone, chaperonin-60. Purified plant chaperonin-60 is distinct in that it contains two polypeptides, p60cpn-60 alpha and p60cpn-60 beta, which have divergent amino acid sequences (Hemmingsen, S. M., and Ellis, R. J. (1986) Plant Physiol. 80, 269-276;
H B Wu, L P Cloney, Sean M. Hemmingsen
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PLoS ONE, 2014 The human Aβ peptide causes progressive paralysis when expressed in the muscles of the nematode worm, C. elegans. We have exploited this model of Aβ toxicity by carrying out an RNAi screen to identify genes whose reduced expression modifies the severity ...
Eleonora Khabirova +8 more
doaj +1 more source