Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats [PDF]
, 2000 Early pregnancy factor (EPF), an extracellular chaperonin 10 homologue, has immunosuppressive and growth factor properties. In order to carry out more extensive studies on the in vivo characteristics of EPF, a recombinant form of the molecule has been ...
Murphy, R M +7 more
core +1 more source
The chaperonin 60 protein SlCpn60α1 modulates photosynthesis and photorespiration in tomato [PDF]
Journal of Experimental Botany, 2020 Abstract Photosynthesis, an indispensable biological process of plants, produces organic substances for plant growth, during which photorespiration occurs to oxidize carbohydrates to achieve homeostasis. Although the molecular mechanism underlying photosynthesis and photorespiration has been widely explored, the crosstalk between the two
Jie Ye +7 more
openaire +2 more sources
Complex Destabilization in the Mitochondrial Chaperonin Hsp60 Leads to Disease
Frontiers in Molecular Biosciences, 2020 Several neurological disorders have been linked to mutations in chaperonin genes and more specifically to the HSPD1 gene. In humans, HSPD1 encodes the mitochondrial Heat Shock Protein 60 (mtHsp60) chaperonin, which carries out essential protein folding ...
Alejandro Rodriguez +3 more
doaj +1 more source
Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells. [PDF]
PLoS ONE, 2014 To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear.
So Jung Park +11 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar +14 more
doaj +1 more source
Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics
Frontiers in Molecular Biosciences, 2018 The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin protein working together with co-chaperonin 10 kDa heat shock protein (Hsp10).
Qianli Meng +2 more
doaj +1 more source
Potential marker proteins for ozone-induced yield reduction in rice
Advances in Horticultural Science, 2018 Three proteins - a 60-kDa chaperonin (CPN-60), chloroplastic ATP synthase, and enolase 1 - were evaluated as potential markers of ozone-induced yield responses in six rice (Oryza sativa L.) cultivars (‘Kirara 397’, ‘Koshihikari’, ‘Nipponbare’, ‘Takanari’,
H. Sawada +3 more
doaj +1 more source
Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer. [PDF]
PLoS ONE, 2014 Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with
Xiao-shan Li +3 more
doaj +1 more source
GroEL Chaperonin-Based Assay for Early Diagnosis of Scrub Typhus
Diagnostics, 2022 A point-of-care diagnostic for early and rapid diagnosis of scrub typhus caused by Orientia tsutsugamushi is required for prompt and proper treatment of patients presenting with undifferentiated febrile illnesses.
Nitaya Indrawattana +7 more
doaj +1 more source
Cation-mediated interplay of loops in chaperonin-10
, 2006 The ubiquitously occurring chaperonins consist of a large tetradecameric Chaperonin-60, forming a cylindrical assembly, and a smaller heptameric Chaperonin-10.
Sen, Ranjan +4 more
core +2 more sources