Results 41 to 50 of about 13,634 (224)

Comparative genomic analysis of mollicutes with and without a chaperonin system. [PDF]

PLoS ONE, 2018
The GroE chaperonin system, which comprises GroEL and GroES, assists protein folding in vivo and in vitro. It is conserved in all prokaryotes except in most, but not all, members of the class of mollicutes.
Dominik Schwarz, Orit Adato, Amnon Horovitz, Ron Unger   +3 more
doaj   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Identification of a chaperonin-10 homologue in plant mitochondria

, 1994
Chaperonin-60 and chaperonin-10 form stable binary complexes in the presence of ATP. This phenomenon has been used as the basis for the identification of a chaperonin-10 homologue in potato (Solanum tuberosum L.) mitochondria.
Leaver, C.J., Burt, W.J.E., W.J.E. Burt, C.J. Leaver   +3 more
core   +1 more source

Detection of blueberry stunt phytoplasma in Eastern Canada using cpn60-based molecular diagnostic assays

Scientific Reports, 2021
Blueberry stunt phytoplasma (BBSP; ‘Candidatus Phytoplasma asteris’) is an insect-vectored plant pathogen that causes severe yield losses in blueberry (Vaccinium corymbosum), which is the most valuable fruit crop in Canada.
Christine Hammond, Edel Pérez-López, Jennifer Town, Charles Vincent, Debra Moreau, Tim Dumonceaux   +5 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

Advanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan, Ruimin Chang, Meng Zhang, Qian Dong, Guanxiong Zhang, Xiang Chen, Mingliang Chen, Lixia Lu, Xiaowei Liang, Yeye Guo, Juan Su   +10 more
wiley   +1 more source

Comparative proteomic profiling of human bile reveals SSP411 as a novel biomarker of cholangiocarcinoma. [PDF]

PLoS ONE, 2012
BACKGROUND: Cholangiocarcinoma (CC) is an intractable cancer, arising from biliary epithelial cells, which has a poor prognosis and is increasing in incidence.
Jian Shen, Weizhi Wang, Jindao Wu, Bing Feng, Wen Chen, Meng Wang, Jincao Tang, Fuqiang Wang, Feng Cheng, Liyong Pu, Qiyun Tang, Xuehao Wang, Xiangcheng Li   +12 more
doaj   +1 more source

Streamlining Diagnosis of Bardet–Biedl Syndrome: New Diagnostic Algorithm With Updated Criteria

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Considerable advances have been made in our understanding of Bardet–Biedl syndrome (BBS), particularly in its core clinical features and molecular genetics, warranting an update to the existing diagnostic criteria framework. Using a rigorous, evidence‐based, and consensus‐driven process, a multidisciplinary group of international experts and ...
Jeremy J. Pomeroy, Jesse Richards, Brooke R. Sweeney, Seema Kumar, Katie E. Queen, Joshua Zaritsky, Carl H. Cramer, Elias I. Traboulsi, Brittni A. Scruggs, Erica E. Davis, Ekaterina Keifer, Emma McGibbon, Timothy Ogden, Bendert De Graaf, Tonia Hymers, Elizabeth Forsythe, Philip Beales   +16 more
wiley   +1 more source

B-cell epitopes in GroEL of Francisella tularensis. [PDF]

PLoS ONE, 2014
The chaperonin protein GroEL, also known as heat shock protein 60 (Hsp60), is a prominent antigen in the human and mouse antibody response to the facultative intracellular bacterium Francisella tularensis (Ft), the causative agent of tularemia.
Zhaohua Lu, Michael J Rynkiewicz, Guillermo Madico, Sheng Li, Chiou-Ying Yang, Hillary M Perkins, Seshi R Sompuram, Vani Kodela, Tong Liu, Timothy Morris, Daphne Wang, Marly I Roche, Barbara A Seaton, Jacqueline Sharon   +13 more
doaj   +1 more source

Detection of immunoreactive proteins of Escherichia coli, Streptococcus uberis, and Streptococcus agalactiae isolated from cows with diagnosed mastitis

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionMastitis is a widespread mammary gland disease of dairy cows that causes severe economic losses to dairy farms. Mastitis can be caused by bacteria, fungi, and algae.
Anna Dobrut, Dagmara Wójcik-Grzybek, Agata Młodzińska, Dorota Pietras-Ożga, Katarzyna Michalak, Aleksander Tabacki, Urszula Mroczkowska, Monika Brzychczy-Włoch   +7 more
doaj   +1 more source

Immunochemical localization of a region of chaperonin-60 important for productive interaction with chaperonin-10.

Journal of Biological Chemistry, 1992
An IgG1 monoclonal antibody (mAb 54G8) which binds to both Bordetella pertussis chaperonin-60 (cpn60) and Escherichia coli cpn60 (GroEL) was produced. mAb 54G8 as well as Fab fragments prepared from this antibody were found to abolish the ability of chaperonin-10 (cpn10, GroES) to inhibit the ATPase activity of both B. pertussis cpn60 and E. coli cpn60.
D L, Burns, M, Kessel, J L, Arciniega, A, Karpas, J, Gould-Kostka   +4 more
openaire   +2 more sources