The chaperonin 60 protein SlCpn60α1 modulates photosynthesis and photorespiration in tomato [PDF]
Journal of Experimental Botany, 2020 Abstract Photosynthesis, an indispensable biological process of plants, produces organic substances for plant growth, during which photorespiration occurs to oxidize carbohydrates to achieve homeostasis. Although the molecular mechanism underlying photosynthesis and photorespiration has been widely explored, the crosstalk between the two
Jie Ye +7 more
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The Journal of Clinical Investigation, 2022 Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative and proteotoxic stress in mitochondria must be attenuated by the activation of
Rahul Kumar +14 more
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Chaperonin 60 unfolds its secrets of cellular communication
Cell Stress & Chaperones, 2002 The cell biology of the chaperonins (Cpns) has been intensively studied over the past 25 years. These ubiquitous and essential molecules assist proteins to fold into their native state and function to protect proteins from denaturation after stress.
Maria, Maguire +2 more
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Toward Developing Chemical Modulators of Hsp60 as Potential Therapeutics
Frontiers in Molecular Biosciences, 2018 The 60 kDa heat shock protein (Hsp60) is classically known as a mitochondrial chaperonin protein working together with co-chaperonin 10 kDa heat shock protein (Hsp10).
Qianli Meng +2 more
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GroEL Chaperonin-Based Assay for Early Diagnosis of Scrub Typhus
Diagnostics, 2022 A point-of-care diagnostic for early and rapid diagnosis of scrub typhus caused by Orientia tsutsugamushi is required for prompt and proper treatment of patients presenting with undifferentiated febrile illnesses.
Nitaya Indrawattana +7 more
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Affinity of chaperonin-60 for a protein substrate and its modulation by nucleotides and chaperonin-10 [PDF]
Biochemical Journal, 1994 The refolding of lactate dehydrogenase fully unfolded in 4 M guanidinium chloride was initiated by dilution into assay buffer, and the emergence of active enzyme was recorded. This was performed in the presence of the following chaperonin complexes in the refolding medium: chaperonin-60 (cpn60), cpn60-MgATP, cpn60-Mgp[NH]ppA, cpn60-MgADP in both the ...
Staniforth, RA +3 more
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Potential marker proteins for ozone-induced yield reduction in rice
Advances in Horticultural Science, 2018 Three proteins - a 60-kDa chaperonin (CPN-60), chloroplastic ATP synthase, and enolase 1 - were evaluated as potential markers of ozone-induced yield responses in six rice (Oryza sativa L.) cultivars (‘Kirara 397’, ‘Koshihikari’, ‘Nipponbare’, ‘Takanari’,
H. Sawada +3 more
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Heat shock protein 60 overexpression is associated with the progression and prognosis in gastric cancer. [PDF]
PLoS ONE, 2014 Heat shock protein 60 (HSP60) is a chaperonin with essential functions for cell physiology and survival, and its expression correlates with prognosis in a number of malignancies. The aim of this study is to determine the relationship of HSP60 status with
Xiao-shan Li +3 more
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Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure. [PDF]
, 2020 To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases.
Chen, Ju +13 more
core
Optimizing a PCR protocol for cpn60-based microbiome profiling of samples variously contaminated with host genomic DNA. [PDF]
, 2015 The current recommended protocol for chaperonin-60 (cpn60) universal target based microbiome profiling includes universal PCR of microbiome samples across an annealing temperature gradient to maximize the diversity of sequences amplified.
Chaban, B +3 more
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