Results 71 to 80 of about 8,317 (219)
Functions of J‐domain proteins in mitochondrial protein biogenesis
Protein Science, Volume 35, Issue 4, April 2026.Abstract
Mitochondrial biogenesis and functions depend on the import and assembly of more than 1000 proteins that are made as precursors on cytosolic ribosomes. The majority of these precursor proteins are transported from the ribosome to the translocase of the outer membrane (TOM complex), which constitutes the main entry site for mitochondrial ...Vitasta Tiku, Georg Bossenz, Janine Kirstein, Thomas Becker +3 morewiley +1 more sourceLachnospiraceae‐Derived Extracellular Vesicles Mediate the Cardioprotective Effects of Barley Leaf in Myocardial Infarction by Improving Intestinal Stem Cell Function
Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.ABSTRACT
Ischaemic cardiovascular diseases, particularly myocardial infarction (MI), remain the leading causes of morbidity and mortality worldwide. Targeting extracellular vesicles (EVs) from the gut microbiota by diet may provide opportunities to improve cardiovascular health. Barley leaf (BL) has a long history of use in Traditional Chinese medicine Wenjing Chen, Yifan Zhao, Qian Zhao, Yingzhuo Zhou, Chen Ma, Li Dong, Yinghua Luo, Zhong Zhang, Fang Chen, Xiaosong Hu, Daotong Li +10 morewiley +1 more sourceFlow Cytometry Role in Unlocking New Frontiers for Nanomedicine Applications of Plant‐Derived Vesicles
Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.ABSTRACT
Extracellular vesicles (EVs) are nanoscale membrane‐bound vesicles released by any cell type under both physiological and pathological conditions. They carry a wide array of bioactive molecules, including microRNAs (miRNAs), lipids, proteins and other small biomolecules, and therefore play a key role in intercellular communication by ...Tamer Esmail, Sabino Porro, Francesca D'Ascanio, Domenico De Bellis, Arianna Aquilini‐Mummolo, Giulia Colasante, Pasquale Simeone, Ayesha Younas, Marwa Balaha, Mariagiulia Filoso, Luana D'Onofrio, Melania Dovizio, Eleonora Aruffo, Piero Di Carlo, Lorenzo Secondi, Federica Flamminii, Tiziana Pietrangelo, Chiara Porro, Patrizia Ballerini, Angelo Cichelli, Paola Lanuti +20 morewiley +1 more sourceThe disruption of proteostasis in neurodegenerative diseases [PDF]
, 2015 Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. 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Park S-H, et al., Taylor RC, Dillin A, Thomas M, Harrell JM, Morishima Y, et al., Tonoki A, Kuranaga E, Tomioka T, et al., Tullet J, Udan-Johns M, Bengoechea R, Bell S, et al., Ullrich O, Reinheckel T, Sitte N, et al., Urano F, Wang X, Bertolotti A, et al., Van den Berg B, Ellis RJ, Dobson CM, Van Ham TJ, Holmberg MA, van der Goot AT, et al., Van Oosten-Hawle P, Morimoto RI, Van Oosten-Hawle P, Porter RS, Morimoto RI, Vashist S, Ng DTW, Von Mikecz A, Vujanac M, Fenaroli A, Zimarino V, Walker LC, LeVine H, Walter P, Ron D, Wandinger SK, Richter K, Buchner J, Wang F, Durfee LA, Huibregtse JM, Wang G, Mao Z, Wang L, Xie C, Greggio E, et al., Wang S, Kaufman RJ, Wanrooij S, Falkenberg M, Warrick JM, Chan HYE, Gray-Board GL, et al., Warrick JM, Paulson HL, Gray-Board GL, et al., Waza M, Adachi H, Katsuno M, et al., Weibezahn J, Tessarz P, Schlieker C, et al., Westerheide SD, Anckar J, Stevens SM, et al., Whitesell L, Lindquist S, Wook Oh S, Mukhopadhyay A, Dixit BL, et al., Wyttenbach A, Xie J, Tang L, Lu L, et al., Xu D, Zalmas LP, La Thangue NB, Xu Y, Cai M, Yang Y, et al., Xu Z, Horwich AL, Sigler PB, Yamamoto K, Sato T, Matsui T, et al., Ye J, Rawson RB, Komuro R, et al., Yoshida H, Matsui T, Yamamoto A, et al., Yoshida H, Oku M, Suzuki M, et al., Yoshida H, Uemura A, Mori K, Young JC, Barral JM, Ulrich Hartl F, Yu A, Shibata Y, Shah B, et al., Zhang Y, Lu H, Bargmann CI, Zhao Q, Wang J, Levichkin IV, et al., Zietkiewicz S, Lewandowska A, Stocki P, et al., Zolkiewski M, Zou J, Guo Y, Guettouche T, et al. +251 morecore +2 more sourcesShade‐induced transcriptional reprogramming and metabolic adaptation in contrasting soybean genotypes
The Plant Genome, Volume 19, Issue 1, March 2026.Abstract
Shade stress affects soybean yield in intercropping, but the molecular basis of cultivar‐specific tolerance is unclear. We analyzed shade‐tolerant (Guru) and sensitive (Heinong 53) soybeans under 30% and 70% shade using transcriptomic, physiological, and biochemical methods.Fengyi Zhang, Runnan Zhou, Rongqiang Yuan, Xiao Zhu, Xinyue Zhang, Sobhi F. Lamlom, Dai Shi, Ahmed M. Abdelghany, Jidao Du, Honglei Ren, Lijuan Qiu +10 morewiley +1 more sourceThe role of molecular chaperonins in warm ischemia and reperfusion injury in the steatotic liver: A proteomic study [PDF]
, 2012 BACKGROUND: The molecular basis of the increased susceptibility of steatotic livers to warm ischemia/reperfusion (I/R) injury during transplantation remains undefined. Animal model for warm I/R injury was induced in obese Zucker rats.Christopher D Anderson, Gundumi Upadhya, James Malone, Jane Liaw-Conlin, Jianluo Jia, Kendra D Conzen, Krista Csontos, R Townsend, Robnet Kerns, Sabarinathan Ramachandran, Thallachallour Mohanakumar, Venkataswarup Tiriveedhi, William C Chapman +12 morecore +2 more sourcesDecreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target
Aging Cell, Volume 25, Issue 3, March 2026.By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...Mingzhu Zhang, Ziqi Hu, Shengwen Piao, Yingrui Song, Ying Jia, Jiaxing Liu, Ning Zhao, An Liu, Songbin Fu, Wenjing Sun, Hui Xu, Yu Yang, Steven P. Gygi, Chunshui Zhou +13 morewiley +1 more sourceBardet-Biedl Syndrome as a Chaperonopathy: Dissecting the Major Role of Chaperonin-Like BBS Proteins (BBS6-BBS10-BBS12)
Frontiers in Molecular Biosciences, 2017 Bardet-Biedl syndrome (BBS) is a rare genetic disorder that belongs to the group of ciliopathies, defined as diseases caused by defects in cilia structure and/or function. The six diagnostic features considered for this syndrome include retinal dystrophy,María Álvarez-Satta, María Álvarez-Satta, María Álvarez-Satta, Sheila Castro-Sánchez, Sheila Castro-Sánchez, Sheila Castro-Sánchez, Diana Valverde, Diana Valverde, Diana Valverde +8 moredoaj +1 more source
