Results 81 to 90 of about 8,317 (219)
Summary Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide biosynthesis and kills plants. Prior activation with bacterial microbe‐associated molecular patterns (MAMPs), such as components of bacterial flagella, effectively suppresses FB1‐induced cell death.
Ali O. Alqarni +3 more
wiley +1 more source
Controlling Geminiviruses before Transmission: Prospects
Whitefly (Bemisia tabaci)-transmitted Geminiviruses cause serious diseases of crop plants in tropical and sub-tropical regions. Plants, animals, and their microbial symbionts have evolved complex ways to interact with each other that impact their life ...
Muhammad Salman Mubarik +11 more
doaj +1 more source
ABSTRACT Heat shock proteins (HSPs) are highly conserved molecular chaperones that maintain proteostasis under environmental and physiological stress. In aquaculture research, HSP responses have been studied primarily in relation to temperature, salinity, pollutants, and pathogens in juvenile and adult stages, whereas the nutritional regulation of HSP ...
Yathish Ramena +3 more
wiley +1 more source
Proteins are macromolecules with a great diversity of functions. By combining these biomolecules with polymers, exciting opportunities for new concepts in polymer sciences arise.
Nico Bruns +5 more
doaj +1 more source
Catalysis of Protein Folding by Chaperones Accelerates Evolutionary Dynamics in Adapting Cell Populations [PDF]
Although molecular chaperones are essential components of protein homeostatic machinery, their mechanism of action and impact on adaptation and evolutionary dynamics remain controversial. Here we developed a physics-based ab initio multi-scale model of a
Shakhnovich, Eugene I. +1 more
core +3 more sources
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source
Chaperonin of Group I: Oligomeric Spectrum and Biochemical and Biological Implications
Chaperonins play various physiological roles and can also be pathogenic. Elucidation of their structure, e.g., oligomeric status and post-translational modifications (PTM), is necessary to understand their functions and mechanisms of action in health and
Silvia Vilasi +13 more
doaj +1 more source
Effects of confinement and crowding on folding of model proteins
We perform molecular dynamics simulations for a simple coarse-grained model of crambin placed inside of a softly repulsive sphere of radius R. The confinement makes folding at the optimal temperature slower and affects the folding scenarios, but both ...
Baruah +26 more
core +1 more source
Proteomics Profiling of Chikungunya-Infected Aedes albopictus C6/36 Cells Reveal Important Mosquito Cell Factors in Virus Replication [PDF]
10.1371/journal.pntd.0003544PLoS Neglected Tropical ...
Chu, Jang Hann, Lee, Regina Ching Hua
core +3 more sources
This study identifies a new viral mechanism by a viral protein σ3 that functions as a vTR to suppress NF‐κB gene expression via its direct interaction with the host helicase DHX9. Through their interaction, σ3 not only impairs the initial recruitment of Pol II but also affects Pol II pause‐release and ultimately suppresses NF‐κB gene expression ...
Xueyang Pang +12 more
wiley +1 more source

