Results 51 to 60 of about 2,955,080 (287)

Modified Characteristic Finite Element Method with Second-Order Spatial Accuracy for Solving Convection-Dominated Problem on Surfaces

Entropy, 2023
We present a modified characteristic finite element method that exhibits second-order spatial accuracy for solving convection–reaction–diffusion equations on surfaces.
Longyuan Wu, Xinlong Feng, Yinnian He
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

The Cauchy–Dirichlet problem for the Moore–Gibson–Thompson equation

Comptes Rendus. Mathématique, 2021
The Cauchy–Dirichlet problem for the Moore–Gibson–Thompson equation is analyzed. With the focus on non-homogeneous boundary data, two approaches are offered: one is based on the theory of hyperbolic equations, while the other one uses the theory of ...
Bucci, Francesca, Eller, Matthias
doaj   +1 more source

Continued fraction solution of Krein's inverse problem

, 2011
The spectral data of a vibrating string are encoded in its so-called characteristic function. We consider the problem of recovering the distribution of mass along the string from its characteristic function.
Borodin A N, Boumenir A, Donati-Martin C, Dym H, Dym H, Dym H, Gantmacher F R, Kac I S, Knight F B, Stieltjes T J, Wall H S, Watanabe S, Yves Tourigny   +12 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A New Characteristic Nonconforming Mixed Finite Element Scheme for Convection-Dominated Diffusion Problem

Journal of Applied Mathematics, 2013
A characteristic nonconforming mixed finite element method (MFEM) is proposed for the convection-dominated diffusion problem based on a new mixed variational formulation.
Dongyang Shi, Qili Tang, Yadong Zhang
doaj   +1 more source

Classical solution for initial–boundary value problem for wave equation with integral boundary condition

Mathematical Modelling and Analysis, 2012
The unique existence of classical solution of initial–boundary value problem for wave equation with a special integral boundary condition is proved in the work. Classical solution of the problem in analytical form is also found in the article.
Victor Korzyuk, Victor Erofeenko, Julia Sheika   +2 more
doaj   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Determination of the characteristic directions of lossless linear optical elements

, 2006
We show that the problem of finding the primary and secondary characteristic directions of a linear lossless optical element can be reformulated in terms of an eigenvalue problem related to the unimodular factor of the transfer matrix of the optical ...
Aben H, Aben H, Asundi A, Born M, Bukhgeim AL, Coker EG, Cook RD, Dankert H, Denisov AM, Ditchburn RW, Engl HW, Fowles GR, Frocht MM, Frocht MM, Fuki AA, Guenther RD, Hammer H, Hanno Hammer *, Hecht E, Helgason S, Holand I, Kirsch A, Longhurst RS, Maxwell JC, Natterer P, Poincaré H, Sommerfeld A, Theocaris PS   +27 more
core   +1 more source