Results 41 to 50 of about 40,876 (272)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Adaptive Generation and Diagnostics of Linear Few-Cycle Light Bullets
Applied Sciences, 2013 Recently we introduced the class of highly localized wavepackets (HLWs) as a generalization of optical Bessel-like needle beams. Here we report on the progress in this field.
Martin Bock, Ruediger Grunwald
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
On a theorem of V.N. Nikolski on characterization of best approximation for convex sets
Journal of Numerical Analysis and Approximation Theory, 1990 Not available.
Ş. Cobzaş
doaj +2 more sources
Improved Shape Parameter Estimation in K Clutter with Neural Networks and Deep Learning
International Journal of Interactive Multimedia and Artificial Intelligence, 2016 The discrimination of the clutter interfering signal is a current problem in modern radars’ design, especially in coastal or offshore environments where the histogram of the background signal often displays heavy tails.
José Raúl Machado Fernández +1 more
doaj +1 more source
PLoS Computational Biology, 2020 The mapping of molecular inputs to their molecular outputs (input/output, I/O mapping) is an important characteristic of gene circuits, both natural and synthetic. Experimental determination of such mappings for synthetic circuits is best performed using
Christoph Stelzer, Yaakov Benenson
doaj +1 more source
Towards a Characterization of Approximation Resistance for Symmetric CSPs [PDF]
, 2015 A Boolean constraint satisfaction problem (CSP) is called approximation resistant if independently setting variables to 1 with some probability achieves the best possible approximation ratio for the fraction of constraints satisfied.
Lee, Euiwoong, Guruswami, Venkatesan
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Characterizations of local best Chebyshev approximations
Journal of Approximation Theory, 1981 AbstractLocal best Chebyshev approximations are characterized by a condition which can be considered as a generalization of the general Kolmogoroff criterion. In the discrete case, this condition is shown to be equivalent to the general Kolmogoroff criterion itself. Finally, local characterizations of the general Kolmogoroff criterion are given.
openaire +2 more sources
Best Approximation and Moduli of Smoothness [PDF]
, 2012 2010 Mathematics Subject Classification: 41A25, 41A10.The aim of this note is to present moduli of smoothness which are introduced by different schools of approximation for characterization of the best algebraic approximation.
Dimova Zapryanova, Teodora
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