Results 41 to 50 of about 357,643 (260)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Construction and Optical Testing of Inflatable Membrane Mirror Using Structured Light Technique

open access: yesInternational Journal of Photoenergy, 2015
Construction and characterization of an inflatable mirror prototype made out of flexible polymeric membranes are being presented. Surfaces were curved by imposing a slight excess of air pressure.
Felipe Patiño-Jiménez   +4 more
doaj   +1 more source

Interdependent Defense Games with Applications to Internet Security at the Level of Autonomous Systems

open access: yesGames, 2017
We propose interdependent defense (IDD) games, a computational game-theoretic framework to study aspects of the interdependence of risk and security in multi-agent systems under deliberate external attacks.
Hau Chan, Michael Ceyko, Luis Ortiz
doaj   +1 more source

CHARACTERIZATIONS AND UNIQUENESS OF BEST SIMULTANEOUS $\tau_C$-APPROXIMATIONS

open access: yesTaiwanese Journal of Mathematics, 2011
This paper is concerned with the problem of best simultaneous $\tau_C$-approximations in terms of the Minkowski functional. The notions of simultaneous sun and simultaneous regular set are extended to suit the case of simultaneous $\tau_C$-approximation problems. Characterization and uniqueness results are established for simultaneous $\tau_C$-suns.
Luo, X. F.   +3 more
openaire   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

On a dual characterisation in best approximation problem

open access: yesJournal of Numerical Analysis and Approximation Theory, 2008
We establish a dual characterization of solutions of Ky Fan best approximation problem and as consequence we obtain an existence criterium under conditions formulated for the weak topology.
Teodor Precupanu
doaj   +2 more sources

Generalized Separable Nonnegative Matrix Factorization

open access: yes, 2019
Nonnegative matrix factorization (NMF) is a linear dimensionality technique for nonnegative data with applications such as image analysis, text mining, audio source separation and hyperspectral unmixing.
Gillis, Nicolas, Pan, Junjun
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Adaptive Generation and Diagnostics of Linear Few-Cycle Light Bullets

open access: yesApplied Sciences, 2013
Recently we introduced the class of highly localized wavepackets (HLWs) as a generalization of optical Bessel-like needle beams. Here we report on the progress in this field.
Martin Bock, Ruediger Grunwald
doaj   +1 more source

Variational Characterizations of Local Entropy and Heat Regularization in Deep Learning

open access: yes, 2019
The aim of this paper is to provide new theoretical and computational understanding on two loss regularizations employed in deep learning, known as local entropy and heat regularization.
Kaplan, Zach   +2 more
core   +1 more source

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