Results 51 to 60 of about 357,643 (260)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

On a theorem of V.N. Nikolski on characterization of best approximation for convex sets

Journal of Numerical Analysis and Approximation Theory, 1990
Not available.
Ş. Cobzaş
doaj   +2 more sources

Improved Shape Parameter Estimation in K Clutter with Neural Networks and Deep Learning

International Journal of Interactive Multimedia and Artificial Intelligence, 2016
The discrimination of the clutter interfering signal is a current problem in modern radars’ design, especially in coastal or offshore environments where the histogram of the background signal often displays heavy tails.
José Raúl Machado Fernández, Jesús Concepción Bacallao Vidal   +1 more
doaj   +1 more source

Precise determination of input-output mapping for multimodal gene circuits using data from transient transfection.

PLoS Computational Biology, 2020
The mapping of molecular inputs to their molecular outputs (input/output, I/O mapping) is an important characteristic of gene circuits, both natural and synthetic. Experimental determination of such mappings for synthetic circuits is best performed using
Christoph Stelzer, Yaakov Benenson
doaj   +1 more source

Uniform and Pointwise Shape Preserving Approximation by Algebraic Polynomials [PDF]

, 2011
We survey developments, over the last thirty years, in the theory of Shape Preserving Approximation (SPA) by algebraic polynomials on a finite interval.
Kopotun, K. A., Leviatan, D., Prymak, A., Shevchuk, I. A.   +3 more
core   +2 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

An Approximation Problem in Multiplicatively Invariant Spaces

, 2016
Let $\mathcal{H}$ be Hilbert space and $(\Omega,\mu)$ a $\sigma$-finite measure space. Multiplicatively invariant (MI) spaces are closed subspaces of $ L^2(\Omega, \mathcal{H})$ that are invariant under point-wise multiplication by functions in a fix ...
Cabrelli, Carlos, Mosquera, Carolina A., Paternostro, Victoria   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Envy Freedom and Prior-free Mechanism Design [PDF]

, 2012
We consider the provision of an abstract service to single-dimensional agents. Our model includes position auctions, single-minded combinatorial auctions, and constrained matching markets.
Devanur, Nikhil R., Hartline, Jason D., Yan, Qiqi   +2 more
core  

New moduli of smoothness

, 2014
In this paper, we discuss various properties of the new modulus of smoothness \[ \omega^\varphi_{k,r}(f^{(r)},t)_p := \sup_{0 < h\leq t}\|\mathcal W^r_{kh}(\cdot) \Delta_{h\varphi(\cdot)}^k (f^{(r)},\cdot)\|_{L_p[-1,1]}, \] where $\mathcal W_\delta(x) = \
Kopotun, K. A., Leviatan, D., Shevchuk, I. A.   +2 more
core   +1 more source