Results 71 to 80 of about 42,681 (238)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Empirical Rules for Oscillation and Harmonic Approximation of Fractional Kelvin–Voigt Oscillators

Applied Sciences
Fractional Kelvin–Voigt (FKV) oscillators describe vibrations in viscoelastic structures with memory effects, leading to dynamics that are often more complex than those of classical harmonic oscillators.
Paweł Łabędzki
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

CHARACTERIZATIONS OF ELEMENTS OF BEST APPROXIMATION AND ε-APPROXIMATION IN NON-ARCHIMEDEAN NORMED SPACES

Demonstratio Mathematica, 1997
Let \(X\) be a non-archimedean (n.a.) normed space over a nontrivially valued field \(F,G\) be a linear subspace of \(X\), \(x\in X\setminus \overline G\) and \(\varepsilon>0\). An element \(g_0\in G\) is said to be a best approximation to \(x\) if \(|x-g_0|= d(x,G)\), and \(\varepsilon\)-approximation to \(x\) if \(|x-g_0 |\leq d(x,G) +\varepsilon ...
openaire   +1 more source

Advancing Age Modulates Associations Between Cognitive Impairment and Brain Volumes in Early MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Cognitive impairment is common in multiple sclerosis (MS), but manifestations following the first demyelinating event are relatively unexplored. We investigated cross‐sectional associations between magnetic resonance imaging (MRI)–derived brain volumes and the presence of cognitive impairment outcomes five years after the first ...
Piriyankan Ananthavarathan, Marco Pitteri, Michael Foster, Sara Collorone, Sara Salama, Elisa Colato, Ferran Prados, Baris Kanber, Marios Yiannakas, Claudia A. M. Gandini Wheeler‐Kingshott, Indran Davagnanam, Frederik Barkhof, Declan Chard, Olga Ciccarelli, Ahmed Toosy   +14 more
wiley   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Memory and Resting‐State Connectivity in Acute Transient Global Amnesia: A Case–Control fMRI Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Transient global amnesia (TGA) is a striking model of isolated amnesia. While hippocampal lesions are well described, the network‐level mechanisms and the precise neuropsychological profile remain debated. Our objective was thus to characterize functional and neuropsychological correlates of acute TGA and their ...
Elias El Otmani, Emmanuel Barbeau, Béatrice Lemesle, Emilie Milongo‐Rigal, Sophie Fernandez, Sandrine Charpentier, Jean‐François Albucher, Nicolas Raposo, Fabrice Bonneville, Patrice Péran, Jérémie Pariente   +10 more
wiley   +1 more source

Sustainable Thermal Energy Storage Systems: A Mathematical Model of the “Waru-Waru” Agricultural Technique Used in Cold Environments

Energies
The provision of food in pre-Inca/Inca cultures (1000 BC–≈1532 AD) in environments near Lake Titikaka (approximately 4000 m above sea level) was possible through an agricultural technique called “Waru-Waru”, which consists of filling the space (volume ...
Jorge Luis Mírez Tarrillo
doaj   +1 more source

Characterization for best nonlinear approximations: A geometrical interpretation

Journal of Approximation Theory, 1975
AbstractThe present paper deals with several characterization theorems for best approximation in normed vector spaces by nonlinear elements. Guided by the outstanding results of Singer in the linear theory, some results of Laurent and Brosowski are generalized so as to obtain a unified approach for the linear and nonlinear approximation theory ...
openaire   +1 more source