Results 11 to 20 of about 231,349 (305)
Negative Immune Checkpoint Inhibitors
PharmaceuticsCheckpoint inhibitors are a modern therapeutic approach for treating various types of cancer, metabolic diseases, and chronic infections. The main goal of this therapy is to specifically unlock the immune system, allowing it to recognize and eliminate ...
Magda Drewniak-Świtalska +2 more
doaj +4 more sources
Checkpoint inhibitors and the gut [PDF]
Journal of Clinical Medicine, 2022 Checkpoint inhibitors have revolutionized treatments in modern oncology, including many conditions previously relegated to palliative therapies only. However, emerging recognition of checkpoint inhibitor-related adverse events has complicated the status ...
Tran, Nguyen G. +5 more
core +5 more sources
Immune checkpoint inhibitors [PDF]
Journal of Cell Biology, 2019 Hui details the cell biology underlying the action of immune checkpoint ...
Hui, Enfu, Enfu Hui
core +5 more sources
Checkpoint Inhibitors and Hepatotoxicity [PDF]
Biomedicines, 2021 Uncontrolled immune response to a pathogen or any protein can lead to tissue damage and autoimmune diseases, that represent aberrant immune responses of the individual to its own cells and/or proteins.
Stephen D. H. Malnick +2 more
doaj +3 more sources
Brazilian Journal of Oncology, 2022 Objectives: To report real-world data of a cohort of patients treated with immune-checkpoint inhibitors in Brazil, with focus in immune-related adverse events.
Maria Paula Furtado Santos +9 more
doaj +2 more sources
Nephrotoxicity of checkpoint inhibitors; a current challenge [PDF]
Journal of NephropharmacologyImmune checkpoint inhibitors work by blocking the "checkpoint" mechanism that tumors use to hide from the immune system, therefore also weakening the immune system.
Samaneh Zandifar +4 more
doaj +2 more sources
Cardiotoxicity of immune checkpoint inhibitors
ESMO Open, 2017 Cardiac toxicity after conventional antineoplastic drugs (eg, anthracyclines) has historically been a relevant issue. In addition, targeted therapies and biological molecules can also induce cardiotoxicity.
Gilda Varricchi +15 more
core +4 more sources
Recent Patents on Anti-Cancer Drug Discovery, 2006 Cell cycle ckeckpoints are activated in response to DNA damage. Their role consists in blocking the cell cycle to allow time for DNA repair. The activity of the G1 checkpoint is dependent on the p53 protein. In more than 50% of human tumor cells, the p53
Prudhomme, Michelle
core +4 more sources
Checkpoint inhibitors in hematological malignancies [PDF]
Journal of Hematology & Oncology, 2017 Inhibitory molecules such as PD-1, CTLA-4, LAG-3, or TIM-3 play a role to keep a balance in immune function. However, many cancers exploit such molecules to escape immune surveillance.
Ken H. Young, Chi Young Ok
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Immune Checkpoint Inhibitors in Gliomas
Current Oncology Reports, 2017 PURPOSE OF REVIEW: Malignant gliomas result in disproportionately high morbidity and mortality compared with other primary tumors, and progression of disease is inevitable.
AB Heimberger (14461521) +2 more
core +3 more sources