Results 31 to 40 of about 231,349 (305)
Frontiers in Oncology, 2020 The immune checkpoint inhibitors opened a new era for the treatment of melanoma. Nowadays, combined immune checkpoint inhibitors are administered to provide additive or synergistic effects on anti-melanoma immunity.
S. Morteza Seyed Jafari +2 more
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Frontiers in Cell and Developmental Biology, 2020 Therapies that target oncogenes and immune checkpoint molecules constitute a major group of treatments for metastatic melanoma. A mutation in BRAF (BRAF V600E) affects various signaling pathways, including mitogen activated protein kinase (MAPK) and PI3K/
Minjeong Yeon +3 more
doaj +1 more source
Checkpoint inhibitors for malignant melanoma: a systematic review and meta-analysis [PDF]
, 2017 Background and Objectives Rates of malignant melanoma are continuing to increase, and, until recently effective treatments were lacking. Since 2011, three immunotherapeutic agents, known as checkpoint inhibitors, have, however, been approved. This review
Saleh SN +5 more
core +1 more source
Cardiotoxicity of Immune Checkpoint Inhibitors [PDF]
Current Oncology Reports, 2021 Immune checkpoint inhibitors (ICIs) have improved the survival of several cancers. However, they may cause a wide range of immune-related adverse events (irAEs). While most irAEs are manageable with temporary cessation of ICI and immunosuppression, cardiovascular toxicity can be associated with high rates of morbidity and mortality.
Rushin P. Patel +6 more
openaire +2 more sources
Cancer Biology & Medicine, 2015 Immune checkpoint inhibitors are increasingly drawing much attention in the therapeutic development for cancer treatment. However, many cancer patients do not respond to treatments with immune checkpoint inhibitors, partly because of the lack of tumor ...
Jennifer Kleponis +2 more
doaj +1 more source
Determinants of Resistance to Checkpoint Inhibitors [PDF]
International Journal of Molecular Sciences, 2020 The development of immune checkpoint inhibitors (ICIs) has drastically altered the landscape of cancer treatment. Since approval of the first ICI for the treatment of advanced melanoma in 2011, several therapeutic agents have been Food and Drug Administration (FDA)-approved for multiple cancers, and hundreds of clinical trials are currently ongoing ...
Linda Tran, Dan Theodorescu
openaire +2 more sources
Frontiers in Immunology, 2017 Immune checkpoint inhibitors, which target coinhibitory T cell molecules to promote anticancer immune responses, are on the rise to become a new pillar of cancer therapy.
Carmen Stecher +7 more
doaj +1 more source
Molecular Architecture of the DNA Replication Origin Activation Checkpoint [PDF]
, 2010 Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication initiation and dissect this checkpoint in fibroblasts.
Claire Mulvey +13 more
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The role of immune checkpoint inhibitors in the development and treatment of infectious processes [PDF]
Клиническая практикаThe incidence and prevalence of oncological diseases, which are the second most frequent cause of death, is steadily increasing among the population of the Russian Federation.
Dilya A. Mustafina +13 more
doaj +1 more source
Melanoma Management, 2019 Aim: To describe treatment changes from 2011 to 2017 and demographic/clinical characteristics of patients with advanced melanoma who received systemic therapy by BRAF status.
Shweta Shah +4 more
doaj +1 more source