Results 121 to 130 of about 4,480,665 (367)

Mechanoresponsive Hydrogels Emerging from Dynamic and Non‐Covalent Interactions

Advanced Materials, EarlyView.
Mechanoresponsive behaviors in hydrogels often arise from dynamic or non‐covalent interactions between polymer chains. This review highlights self‐healing, shear‐thinning, shear‐thickening, and strain‐stiffening hydrogels formed through dynamic crosslinking motifs, discussing their underlying mechanisms and emergent applications across biomedical and ...
Rachel C. Ollier, Matthew J. Webber
wiley   +1 more source

A randomized trial of amlodipine in addition to standard chelation therapy in patients with thalassemia major.

Blood, 2016
Cardiovascular disease resulting from iron accumulation is still a major cause of death in patients with thalassemia major (TM). Voltage-gated calcium-channel blockade prevents iron entry into cardiomyocytes and may provide an adjuvant treatment to ...
J. Fernandes, S. Loggetto, Mônica P A Veríssimo, K. Fertrin, G. Baldanzi, L. A. Fioravante, D. Tan, T. Higa, D. A. Mashima, A. Piga, O. Coelho, F. Costa, S. Saad   +12 more
semanticscholar   +1 more source

Zinc‐Coordinated Trienzyme Nanogel Cascade Therapy for Accelerated Post‐Pancreatectomy Cutaneous Wound Healing

Advanced Materials, EarlyView.
A zinc‐coordinated nanogel assembly is reported that co‐delivers three enzymes to regulate glucose, oxidative stress, and oxygen levels. This system mimics natural enzyme cascades to reprogram the wound environment after pancreatectomy. In a post‐pancreatectomy mouse model, it accelerates healing by reducing infection, promoting blood vessel growth ...
Yedong Ma, Chengke Xie, Chengyu Liao, Binting Huang, Siqi Liu, Junhua Kong, Xiaotong Fan, Zibiao Li, Shi Chen, Chaobin He   +9 more
wiley   +1 more source

Bright LaF3:Eu@Ir Phosphors Combining Two‐Photon Excitation, d → f Energy Transfer and Tunable Time‐Gated Chromaticity for Multicolor Cell Imaging

Advanced Optical Materials, EarlyView.
The surface functionalization of Eu‐doped LaF3 particles with a two‐photon absorbing IrIII complex results in the formation of ultrabright Eu:LaF3 phosphors, which exhibit a combination of short‐lived IrIII and long‐lived EuIII‐sensitized emissions. These Ir/Eu hybrids are effectively internalized by HEK‐293 cells without causing toxic effects, thereby
Yating Ye, Mattia Bramini, Paola Sánchez‐Moreno, Angel Orte, Juan‐Ramón Jiménez, Juan Manuel Herrera   +5 more
wiley   +1 more source

Intracellular Monitoring of Luminescent Ag2S Nanoparticles in Fibroblasts

Advanced Optical Materials, EarlyView.
This study investigates the long‐term luminescence behavior of Ag2S quantum dots (AS QDs) with three surface ligands (DTDTPA, 11MUA, PEG) in fibroblasts over 9 days. AS‐PEG showed stable uptake and enhanced NIR‐II emission, while others decreased due to oxidative stress.
Mahshid Hashemkhani, Thomas Naillon, Lise Abiven, Stéphane Roux, Bruno Viana, Corinne Chanéac, Florence Gazeau   +6 more
wiley   +1 more source

Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma

Nature Communications
Anti-disialoganglioside (GD2) antibody therapy has provided clinical benefit to patients with neuroblastoma however efficacy is likely impaired by the immunosuppressive tumor microenvironment. We have previously defined a link between intratumoral copper
Jourdin R. C. Rouaen, Antonietta Salerno, Tyler Shai-Hee, Jayne E. Murray, Giulia Castrogiovanni, Charlotte McHenry, Toni Rose Jue, Vu Pham, Jessica Lilian Bell, Ensieh Poursani, Emanuele Valli, Riccardo Cazzoli, Naomi Damstra, Delia J. Nelson, Kofi L. P. Stevens, Jonathan Chee, Iveta Slapetova, Maria Kasherman, Renee Whan, Francis Lin, Blake J. Cochran, Nicodemus Tedla, Feyza Colakoglu Veli, Aysen Yuksel, Chelsea Mayoh, Federica Saletta, Daniele Mercatelli, Tatyana Chtanova, Arutha Kulasinghe, Daniel Catchpoole, Giuseppe Cirillo, Maté Biro, Holger N. Lode, Fabio Luciani, Michelle Haber, Juliet C. Gray, Toby N. Trahair, Orazio Vittorio   +37 more
doaj   +1 more source

Durable Red Blood Cell Transfusion Independence in a Patient with an MDS/MPN Overlap Syndrome Following Discontinuation of Iron Chelation Therapy

Case Reports in Hematology, 2015
Background. Hematologic improvement (HI) occurs in some patients with acquired anemias and transfusional iron overload receiving iron chelation therapy (ICT) but there is little information on transfusion status after stopping chelation. Case Report.
Harpreet Kochhar, Chantal S. Leger, Heather A. Leitch   +2 more
doaj   +1 more source

Iron overload and chelation therapy in hemoglobinopathies

Thalassemia Reports, 2018
Iron overload (IOL) is highly prevalent among patients with hemoglobinopathies; both transfusion dependent thalassemia (TDT) and non-transfusion dependent thalassemia (NTDT).
Rayan Bou-Fakhredin, Joseph Elias, Ali T. Taher   +2 more
doaj   +1 more source

Chronic hyperplastic anemia as an independent risk factor for atherosclerotic lesions: a lesson from thalassemia intermedia [PDF]

, 2010
Introduction. Cardiovascular involvement represents a well-known complication and the primary cause of mortality, both in transfusion-dependent beta thalassemia major (β-TM) and in transfusion-independent beta thalassemia intermedia (β-TI ...
Alessandra Spiga, Antonella Mandas, Fabrizio Angius, Maria Eliana Lai, Maria Paola Carta, Pier Luigi Cocco, Sandra Dessi, Stefania Vacquer   +7 more
core   +1 more source

Near‐Infrared‐Driven Metal–Organic Frameworks‐Based Nanorobots for Controlled Photothermal‐Chemical Therapy Synergistic Induction of Cancer Cell Death

Advanced Robotics Research, EarlyView.
To achieve efficient cancer cell death, a bowl‐shaped PDA@UiO‐66@DOX nanorobot drug‐delivery nanoplatform was developed. Near‐infrared irradiation not only drives the nanorobot to exhibit self‐thermophoretic motion and elevates temperature but also triggers Doxorubicin (DOX) release via hyperthermia, enhancing cancer cells uptake of DOX and thereby ...
Tong Lin, Jie Yang, Yongcheng Li, Yuepeng Cai, Xiaosong Zhou, Ting Chen, Renfeng Dong   +6 more
wiley   +1 more source