Results 141 to 150 of about 28,637 (186)
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European Journal of Haematology, 2023
AbstractIron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance.
Antonella Bruzzese +11 more
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AbstractIron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance.
Antonella Bruzzese +11 more
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Efficacy of chelation therapy to remove aluminium intoxication [PDF]
Journal of Inorganic Biochemistry, 2015 There is a distinct correlation between aluminium (Al) intoxication and neurodegenerative diseases (ND). We demonstrated how patients affected by ND showing Al intoxication benefit from short-term treatment with calcium disodium ethylene diamine ...
Maria Elena Ferrero +1 more
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Chelation Therapy in Atherosclerosis
Annals of Internal Medicine, 1982Excerpt To the editor: A number of inquiries have been made to the West Virginia University Drug Information Center requesting information on the value of edetate disodium (EDTA) in chelation thera...
J G, Stevenson, T R, Covington
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CRC Critical Reviews in Clinical Laboratory Sciences, 1988
Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko +2 more
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Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko +2 more
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Journal of the American Medical Association, 1958
Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN +3 more
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Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN +3 more
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Current Opinion in Hematology, 1995
Iron chelation therapy is essential to prevent death from cardiac toxicity in patients with thalassemia major or other severe refractory anemias who need regular blood transfusions. Iron chelating drugs also have potential for clinical use as antiproliferative agents in neoplastic diseases and to reduce free radical-induced tissue damage in rheumatoid ...
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Iron chelation therapy is essential to prevent death from cardiac toxicity in patients with thalassemia major or other severe refractory anemias who need regular blood transfusions. Iron chelating drugs also have potential for clinical use as antiproliferative agents in neoplastic diseases and to reduce free radical-induced tissue damage in rheumatoid ...
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Chelation Therapy for Arteriosclerosis
JAMA: The Journal of the American Medical Association, 1975SOME profess that a certain intravenously administered colorless compound is the elixir of youth. Chelation therapy with edetate disodium (EDTA) solution is described in tones of evangelical fervor in a brochure from a medical clinic: Chelation therapy for hardening of the arteries is a special treatment given by licensed medical doctors for the ...
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Iron overload is a serious complication associated with transfusion-dependent anemias and anemias characterized by ineffective erythropoiesis. Iron accumulation is toxic to many tissues, causing heart failure, cirrhosis, liver cancer, growth retardation, and multiple endocrine abnormalities.Chelation therapy aims to balance the rate of iron ...
Cappellini, Maria Domenica +3 more
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Cappellini, Maria Domenica +3 more
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Iron Toxicity and Chelation Therapy
International Journal of Hematology, 2002Iron is an essential mineral for normal cellular physiology, but an excess can result in cell injury. Iron in low-molecular-weight forms may play a catalytic role in the initiation of free radical reactions. The resulting oxyradicals have the potential to damage cellular lipids, nucleic acids, proteins, and carbohydrates; the result is wide-ranging ...
Robert S, Britton +2 more
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Chelation Therapy in Lead Nephropathy
Southern Medical Journal, 1975Although treatment has been well defined for childhood lead poisoning and for industrial lead exposure, the treatment of lead nephropathy has been poorly studied. The available chelating agents are reviewed and the results of treatment in 17 cases of lead nephropathy are shown.
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