Results 1 to 10 of about 32,578 (113)

2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy

Bioactive Materials, 2022
An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation, tumor progression and metastasis. This makes iron metabolism an attractive therapeutic target.
Yunjie Xu, Yingwei Wang, Jusung An, Adam C. Sedgwick, Mingle Li, Jianlei Xie, Weibin Hu, Jianlong Kang, Sajal Sen, Axel Steinbrueck, Bin Zhang, Lijun Qiao, Swelm Wageh, Jonathan F. Arambula, Liping Liu, Han Zhang, Jonathan L. Sessler, Jong Seung Kim   +17 more
doaj   +3 more sources

Sex and Gender Differences in Iron Chelation [PDF]

Biomedicines
Background/Objectives: In the absence of physiological mechanisms to excrete excessive iron, the administration of iron chelation therapy is necessary.
Sarah Allegra, Stefano Comità, Antonella Roetto, Silvia De Francia   +3 more
doaj   +2 more sources

The Role of Iron Chelation Therapy in Colorectal Cancer: A Systematic Review on Its Mechanisms and Therapeutic Potential [PDF]

Cancer Medicine
Background Despite significant therapeutic advancements in recent decades, colorectal cancer (CRC) continues to exhibit high rates of mortality and morbidity.
Gihani Vidanapathirana, Md Sajedul Islam, Sujani Gamage, Alfred K. Lam, Vinod Gopalan   +4 more
doaj   +2 more sources

New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases

Pharmaceuticals, 2018
Iron chelation has been introduced as a new therapeutic concept for the treatment of neurodegenerative diseases with features of iron overload. At difference with iron chelators used in systemic diseases, effective chelators for the treatment of ...
Marco T. Nuñez, Pedro Chana-Cuevas
doaj   +3 more sources

Nanosponge for Iron Chelation and Efflux: A Ferroptosis‐Inhibiting Approach for Myocardial Infarction Therapy [PDF]

Advanced Science
Myocardial infarction (MI), a consequence of coronary artery occlusion, triggers the degradation of ferritin, resulting in elevated levels of free iron in the heart and thereby inducing ferroptosis.
Qingbo Lv, Jun Lin, He Huang, Boxuan Ma, Wujiao Li, Jiawen Chen, Meihui Wang, Xiaoyu Wang, Guosheng Fu, Yun Xiao   +9 more
doaj   +2 more sources

Iron Chelation in Local Infection

Molecules, 2021
Iron is an essential element in multiple biochemical pathways in humans and pathogens. As part of the innate immune response in local infection, iron availability is restricted locally in order to reduce overproduction of reactive oxygen species by the ...
Cassidy Scott, Gaurav Arora, Kayle Dickson, Christian Lehmann   +3 more
doaj   +3 more sources

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation [PDF]

Advanced Science
Doxorubicin (DOX)‐induced cardiotoxicity (DIC) has become a major obstacle for clinical application. While ferroptosis represents a critical therapeutic target for DIC, current intervention strategies are limited by spatiotemporal mismatches between DOX ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
doaj   +2 more sources

Cardiac iron overload evaluation in thalassaemic patients using T2* magnetic resonance imaging following chelation therapy: a multicentre cross-sectional study

Hematology, Transfusion and Cell Therapy, 2023
Introduction: Magnetic resonance imaging (MRI) T2* technique is used to assess iron overload in the heart, liver and pancreas of thalassaemic patients. Optimal iron chelation and expected tissue iron response rates remain under investigation.
Eduardo Cerello Chapchap, Murilo Marques Almeida Silva, Reijane Alves de Assis, Lucila Nassif Kerbauy, Michelli da Silva Diniz, Laércio Alberto Rosemberg, Sandra Regina Loggetto, Aderson da Silva Araujo, Antonio Fabron Junior, Monica Pinheiro de Almeida Verissimo, Giorgio Roberto Baldanzi, Breno Pannia Esposito, Fernando Tricta, Merula Emmanoel Anargyrou Steagall, Claudia Ângela Galleni Di Sessa Vellozo, Kleber Yotsumoto Fertrin, Ronaldo Hueb Baroni, Nelson Hamerschlak   +17 more
doaj   +1 more source

A Speciation Study on the Perturbing Effects of Iron Chelators on the Homeostasis of Essential Metal Ions. [PDF]

PLoS ONE, 2015
A number of reports have appeared in literature calling attention to the depletion of essential metal ions during chelation therapy on β-thalassaemia patients.
Guido Crisponi, Valeria Marina Nurchi, Miriam Crespo-Alonso, Gavino Sanna, Maria Antonietta Zoroddu, Giancarla Alberti, Raffaela Biesuz   +6 more
doaj   +1 more source

Compliance and clinical benefit of deferasirox granule and dispersible tablet formulation in pediatric patients with transfusional iron overload: in a randomized, open-label, multicenter, phase II study

Haematologica, 2023
CALYPSO (clinicaltrials gov. Identifier: NCT02435212), a randomized, open-label, multicenter, phase II study evaluated the compliance, clinical benefits, and safety of deferasirox granules and dispersible tablets (DT) in pediatric patients with iron ...
Ali T. Taher, Yasser Wali, Maria Cecilia Cruz, Pimlak Charoenkwan, Yesim Aydinok, Olena Werner, Sameera Govindaraju, Fabian Romen, Vip Viprakasit   +8 more
doaj   +1 more source