Results 21 to 30 of about 32,727 (251)

Iron overload and chelation

Hematology, 2005
Iron is one of the most common elements in nature. As a transition metal it is very efficient in electron transport and redox reactions. The proteins and enzymes in which iron is an essential component play a key role in respiration, energy production, detoxification of harmful oxygen species and cell replication.
Chaim, Hershko, Gabriela, Link, Abraham M, Konijn, Z, Ioav Cabantchik   +3 more
openaire   +2 more sources

Iron Chelation Therapy in Myelodysplastic Syndromes

Advances in Hematology, 2010
Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. In low-risk patients, transfusion dependency can be long lasting, leading to iron overload.
Emanuela Messa, Daniela Cilloni, Giuseppe Saglio   +2 more
doaj   +1 more source

Brazilian Thalassemia Association protocol for iron chelation therapy in patients under regular transfusion

Revista Brasileira de Hematologia e Hemoterapia, 2013
In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload.
Monica Pinheiro de Almeida Verissimo, Sandra Regina Loggetto, Antonio Fabron Junior, Giorgio Roberto Baldanzi, Nelson Hamerschlak, Juliano Lara Fernandes, Aderson da Silva Araujo, Clarisse Lopes de Castro Lobo, Kleber Yotsumoto Fertrin, Vasilios Antonios Berdoukas, Renzo Galanello   +10 more
doaj   +1 more source

An Untargeted Metabolomics Approach for Correlating Pulse Crop Seed Coat Polyphenol Profiles with Antioxidant Capacity and Iron Chelation Ability

Molecules, 2021
Pulse crop seed coats are a sustainable source of antioxidant polyphenols, but are typically treated as low-value products, partly because some polyphenols reduce iron bioavailability in humans.
Fatma M. Elessawy, Albert Vandenberg, Anas El-Aneed, Randy W. Purves   +3 more
doaj   +1 more source

Challenges of Iron Chelation in Thalassemic Children

Thalassemia Reports
Thalassemia treatment still relies on supportive care, mainly including blood transfusion and iron chelation therapy. Iron chelation is considered the main factor responsible for the marked improvement in survival rates of thalassemic patients ...
Alkistis Adramerina, Marina Economou
doaj   +1 more source

Naringin is a promising natural compound for therapy of iron-overload disorders

Brazilian Journal of Pharmaceutical Sciences, 2022
Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be
Mehrdad Jahanshahi, Masoumeh Khalili, Asra Margdari, Mahdi Aalikhani   +3 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Durable Red Blood Cell Transfusion Independence in a Patient with an MDS/MPN Overlap Syndrome Following Discontinuation of Iron Chelation Therapy

Case Reports in Hematology, 2015
Background. Hematologic improvement (HI) occurs in some patients with acquired anemias and transfusional iron overload receiving iron chelation therapy (ICT) but there is little information on transfusion status after stopping chelation. Case Report.
Harpreet Kochhar, Chantal S. Leger, Heather A. Leitch   +2 more
doaj   +1 more source

The role of iron and iron chelators in zygomycosis [PDF]

Clinical Microbiology and Infection, 2009
Iron is an essential element for cell growth and development, contributing to DNA synthesis and regulating the G(1)-phase to S-phase transition. Moreover, iron is important for the virulence of the majority of microorganisms, and the function of the genes regulating iron uptake is coupled with the manifestations of the virulence phenotype.
openaire   +2 more sources

Advances in Solution‐Processed Textile Triboelectric Nanogenerators: Ink Formation, Processing Strategies, Applications, and Challenges

Advanced Functional Materials, EarlyView.
Advanced ink systems for solution‐processed textile triboelectric nanogenerators are systematically summarized, spanning conductive, tribo‐negative, and tribo‐positive layers. By connecting ink chemistry, deposition methods, and device function, the present review reveals the key governing principles of solution development and highlights practical ...
Xinlong Sun, Stephen Beeby
wiley   +1 more source