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Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis
Prenatal Diagnosis, EarlyView.ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell +6 more
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PLANTS, PEOPLE, PLANET, EarlyView.Iron deficiency anaemia remains a major public health challenge in Sub‐Saharan Africa, where population growth, displacement and limited resources heighten nutritional insecurity. We compiled a list of indigenous African underutilized wild food plants and examined their potential for addressing micronutrient deficiencies.
Eltayb Abdellatef +2 more
wiley +1 more source
Phytotherapy Research, EarlyView.Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao +13 more
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The Potential Therapeutic Applications of Copper and Its Complexes and Copper Chelation Therapy
Ankana Ghosh, Pritha Pal
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Beyond Pathology: α‐Synuclein Homeostasis and Three Principles to Guide Research
Movement Disorders Clinical Practice, EarlyView.
Alberto J. Espay, Andrew J. Lees
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Oral iron chelation therapy with deferiprone (L(207)).
, 1998 F. N. Al‐Refaie
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European Journal of Haematology, 2023
AbstractIron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance.
Antonella Bruzzese +11 more
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AbstractIron overload is a pathological condition resulting from a congenital impairment of its regulation, increased intestinal iron absorption secondary to bone marrow erythroid hyperplasia, or a chronic transfusional regimen. In normal conditions, intracellular and systemic mechanisms contribute to maintaining iron balance.
Antonella Bruzzese +11 more
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CRC Critical Reviews in Clinical Laboratory Sciences, 1988
Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko +2 more
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Because of the catalytic action of iron in one-electron redox reactions, it has a key role in the formation of harmful oxygen derivatives and production of peroxidative damage to vital cellular structures. The clinical manifestations of iron overload may be prevented and even reversed by the effective administration of the iron-chelating drug ...
Chaim Hershko +2 more
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Journal of the American Medical Association, 1958
Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN +3 more
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Administration of effective doses of iron in the treatment of iron deficiency anemia is complicated by the fact that iron compounds are not innocuous. Toxicity experiments on dogs and rabbits are here summarized; they showed that the concentration of iron attained in the animal's serum determined the severity of the acute symptoms.
M, FRANKLIN +3 more
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Current Opinion in Hematology, 1995
Iron chelation therapy is essential to prevent death from cardiac toxicity in patients with thalassemia major or other severe refractory anemias who need regular blood transfusions. Iron chelating drugs also have potential for clinical use as antiproliferative agents in neoplastic diseases and to reduce free radical-induced tissue damage in rheumatoid ...
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Iron chelation therapy is essential to prevent death from cardiac toxicity in patients with thalassemia major or other severe refractory anemias who need regular blood transfusions. Iron chelating drugs also have potential for clinical use as antiproliferative agents in neoplastic diseases and to reduce free radical-induced tissue damage in rheumatoid ...
openaire +2 more sources