De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast. [PDF]
Nat CommunJiao X +9 more
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Advances in Bioactive Compounds and Cancer Therapy-Insights from the Special Issue "Bioactive Compounds in Cancers". [PDF]
Int J Mol SciBousbaa H, Cidade H, Silva PMA.
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In vitro antifungal activity and possible mechanisms of action of chelerythrine
Pesticide Biochemistry and Physiology, 2020Chelerythrine (CHE) possesses broad pharmacological activities. In this study, the extract of Chelidonium majus L. were characterized by high performance liquid chromatography (HPLC), infrared radiation (IR) spectroscopy and nuclear magnetic resonance (NMR). It was proved that the extract was CHE.
Xue-Feng Liu, Na Zhao, Min Zhao
exaly +4 more sources
Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid
Bioorganic and Medicinal Chemistry Letters, 2018Chelerythrine, an isoquinoline alkaloid isolated from the herbaceous perennial Chelidonium majus, was found to potently and selectively inhibit an isoform of recombinant human monoamine oxidase-A (MAO-A) with an IC50 value of 0.55 µM. Chelerythrine was a reversible competitive MAO-A inhibitor (Ki = 0.22 µM) with a potency much greater than toloxatone ...
Seung Cheol Baek +2 more
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Chelerythrine is a potent and specific inhibitor of protein kinase C
Biochemical and Biophysical Research Communications, 1990The benzophenanthridine alkaloid chelerythrine is a potent, selective antagonist of the Ca++/phospholopid-dependent protein kinase (Protein kinase C: PKC) from the rat brain. Half-maximal inhibition of the kinase occurs at 0.66 microM. Chelerythrine interacted with the catalytic domain of PKC, was a competitive inhibitor with respect to the phosphate ...
J M, Herbert +3 more
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Therapeutic potential of chelerythrine as a multi-purpose adjuvant for the treatment of COVID-19
Cell Cycle, 2021 Multifunctional nature of phytochemicals and their chemical diversity has attracted attention to develop leads originated from nature to fight COVID-19.
Mehdi Valipour +2 more
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Chelerythrine ameliorates rheumatoid arthritis by modulating the AMPK/mTOR/ULK-1 signaling pathway
Phytomedicine, 2022BACKGROUND Rheumatoid arthritis (RA) is a long-term, progressive, and disabling autoimmune disease. It causes inflammation, swelling and pain in and around the joints and other body organs. Currently, no cure is available for RA.
Ali Adnan Nasim +2 more
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Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. Chelerythrine (CHE), a natural benzophenanthridine alkaloid, has been reported to exhibit the anti-tumor effects in a variety of cancer cells ...
P. Wang +8 more
semanticscholar +1 more source
Chelerythrine chloride inhibits Zika virus infection by targeting the viral NS4B protein.
Antiviral Research, 2023Zika virus (ZIKV) is a mosquito-borne virus that has re-emerged as a significant threat to global health in the recent decade. Whilst infections are primarily asymptomatic, the virus has been associated with the manifestation of severe neurological ...
Marcus Wing Choy Loe +7 more
semanticscholar +1 more source
Structural modification of sanguinarine and chelerythrine and their antibacterial activity
Natural Product Research, 2011In this study, five derivatives of sanguinarine (1) and chelerythrine (2) were prepared, with 1 and 2 as starting materials, by reduction, oxidation and nucleophilic addition to the iminium bond C=N+. The structures of all compounds were elucidated on account of their MS, ¹H-NMR and ¹³C-NMR data.
Le Zhou
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