Results 191 to 200 of about 9,197 (244)

Chelerythrine reverses the drug resistance of resistant Candida albicans and the biofilm to fluconazole.

Future Microbiology, 2022
Aim: To evaluate the antifungal activity of chelerythrine in combination with fluconazole against planktonic Candida albicans strains and preformed biofilm.
Ying Gong, Shulin Yin, Shujuan Sun, Min Li   +3 more
semanticscholar   +1 more source

The Pharmacokinetics of Chelerythrine Solution and Chelerythrine Liposomes after Oral Administration to Rats

Planta Medica, 2013
Chelerythrine is a quaternary benzo[c]phenanthridine alkaloid which has many potent pharmacological effects and can dissolve well in water; dihydrochelerythrine has recently been identified as a chelerythrine metabolite in rat. Most methods of preparation of liposomes suffer from the drawback of poor incorporation of water-soluble drugs.
Weifeng Li, Xiaofeng Niu
exaly   +3 more sources

The pharmacological action of chelerythrine

Journal of the American Pharmaceutical Association (Scientific ed.), 1955
Chelerythrine hydrochloride, has been subjected to a pharmacologic study. Its action was determined on the blood pressure, uterus, and intestine, and the nictitating membrane of eighteen cats and one dog. Chelerythrine lowered the blood pressure in anesthetized cats, preceded by a brief pressor action.
C E, POWELL, K K, CHEN
openaire   +2 more sources

Structure of Chelerythrine Base

Journal of Natural Products, 1995
The structure of chelerythrine free base was examined. When chelerythrine chloride [1b] was treated with aqueous K2CO3 solution, bis[6-(5,6-dihydrochelerythrinyl)] ether [3] was obtained. An excess of aqueous ammonia under the same conditions yielded bis[6-(5,6-dihydrochelerythrinyl)] amine [4].
Jiří Dostál, Eva Táborská, Jiří Slavík, Milan Potáček, Edmond de Hoffmann   +4 more
openaire   +1 more source

Interaction of chelerythrine with inositol phosphate metabolism

Fundamental & Clinical Pharmacology, 2002
Chelerythrine, a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on inositol phosphate (IP) metabolism in newborn rat cardiomyocytes in culture. In a first step, we evaluated the effect of chelerythrine on IP accumulation in basal conditions.
Philippe, Le Corvoisier, Jérôme, Lacotte, Monique, Laplace, Bertrand, Crozatier   +3 more
openaire   +2 more sources

Anti-microbial and anti-biofilm activities of combined chelerythrine-sanguinarine and mode of action against Candida albicans and Cryptococcus neoformans in vitro.

Colloids and Surfaces B: Biointerfaces, 2020
The increasing prevalence of fungal infections coupled with emerging drug resistance has stimulated an urgent need to explore new and effective antifungal agents.
Weidong Qian, Min Yang, Xinchen Li, Zhaohuan Sun, Yongdong Li, Xuejun Wang, Ting Wang   +6 more
semanticscholar   +1 more source

Protective effect of chelerythrine on gentamicin‐induced nephrotoxicity

Cell Biochemistry and Function, 2004
AbstractDespite their beneficial effects, aminoglycosides including gentamicin (GEN) have considerable nephrotoxic side‐effects. The toxicity of GEN at the level of the kidney seems to relate to the generation of reactive oxygen species (ROS). ROS have been reported to be involved in the activation of protein kinase C (PKC).
Bay-Karabulut, AYSUN, UÇAR, MUHARREM, Acet, A., VARDI, NİGAR, Yanilmaz, M., PARLAKPINAR, HAKAN, Kavakli, A., POLAT, ALAADİN, TAŞDEMİR, SERAP   +8 more
openaire   +3 more sources

Chelerythrine hydrochloride inhibits proliferation and induces mitochondrial apoptosis in cervical cancer cells via PI3K/BAD signaling pathway.

Toxicology in Vitro, 2020
Cervical cancer is the fourth most common female cancer worldwide, and drug targeted therapy plays a crucial role in delaying the progression of cervical carcinoma.
Tianfeng Yang, R. Xu, Qi Su, Hongying Wang, Feng Liu, Bingling Dai, Bo Wang, Yanmin Zhang   +7 more
semanticscholar   +1 more source

Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase.

European journal of medicinal chemistry, 2020
As simple analogues of the natural compound chelerythrine, a novel anti-cholinesterase 2-phenylisoquinolin-2-ium scaffold was designed by structure imitation.
Bohang Zhou, Hui Li, Zhiming Cui, Ding Li, Huiling Geng, Jinming Gao, Le Zhou   +6 more
semanticscholar   +1 more source

A biomimetic conversion of berberine into chelerythrine and dihydrochelerythrine

Journal of the Chemical Society, Chemical Communications, 1984
A novel and efficient synthesis of the benzo[c]phenanthridine alkaloids, chelerythrine and dihydrochelerythrine, from berberine was developod via a biogenetic route.
Miyoji Hanaoka, Toshio Motonishi, Chisato Mukai   +2 more
openaire   +1 more source