Results 201 to 210 of about 9,197 (244)

Investigations with the selective PKC inhibitor chelerythrine on human basophils

Agents and Actions, 1994
Modulation of protein kinase C (PKC) activity in basophils (B) can influence IgE-mediated histamine release (HR). The present study investigated the effects of chelerythrine, which inhibits isolated PKC (IC50 0.7 microM), on different activation pathways in B. Fc epsilon RI-mediated HR was strongly inhibited by chelerythrine (86.5 +/- 5.4%, 5 microM, n
E, von Stebut, U, Amon, J M, Herbert, H H, Wolff   +3 more
openaire   +2 more sources

Synthesis of sanguinarine, chelerythrine, and oxysanguinarine

Collection of Czechoslovak Chemical Communications, 1984
Benzo[c]phenanthridines Va and Vb have been prepared by photocyclization of amines IVa and IVb and transformed into the alkaloids sanguinarine (VIa) and chelerythrine (VIb). Oxysanguinarine (XIV) has been prepared from diazoketone XVIII.
openaire   +1 more source

Microarray Analysis of the Chelerythrine-Induced Transcriptome of Mycobacterium tuberculosis

Current Microbiology, 2010
Chelerythrine (a natural quaternary benzophenanthridine alkaloid) is an extract from the roots of Chelidonium majus with potential antimycobacterial activity. To reveal the possible mechanism of action of chelerythrine against Mycobacterium tuberculosis (M.
Junchao, Liang, Fanli, Zeng, Aizhen, Guo, Liqiang, Liu, Na, Guo, Lei, Li, Jing, Jin, Xiuping, Wu, Mingyuan, Liu, Dan, Zhao, Yang, Li, Qi, Jin, Lu, Yu   +12 more
openaire   +2 more sources

Unique Pharmacological Interactions of Taurine and Chelerythrine in the Retina

1998
The effects of taurine and chelerythrine (CHT) on ATP-dependent calcium uptake and the phosphorylation of the approximately 20 kDa phosphoprotein in the retina were compared. In the absence of the CHT, taurine stimulated ATP-dependent calcium uptake and attenuated the phosphorylation of the approximately 20 kDa phosphoprotein.
J D, Militante, J B, Lombardini
openaire   +2 more sources

Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans

Biochimica Et Biophysica Acta - Molecular Cell Research, 1990
Chelerythrine chloride is an antiplatelet agent isolated from Zanthoxylum simulans. Aggregation and ATP release of washed rabbit platelets caused by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin were inhibited by chelerythrine chloride. Less inhibition was observed in platelet-rich plasma.
Feng-Nien Ko, Ih-Sheng Chen, Che-Ming Teng   +2 more
exaly   +3 more sources

Configurations and conformations of sanguinarine and chelerythrine free bases stereoisomers

Journal of Molecular Structure, 2002
Abstract The configurations and conformations of bimolecular aminoacetals of benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine were investigated by NMR spectroscopy, quantum chemical calculations, and X-ray analysis. The results of the complete computational conformational analysis, the calculation of the chemical shielding of the ...
Toušek, J., Dommisse, Roger, Dostál, J., Zak, Z., Pieters, Luc, Marek, R.   +5 more
openaire   +2 more sources

In vitro and in vivo activity of chelerythrine against Candida albicans and underlying mechanisms.

Future Microbiology, 2019
Aim: To evaluate whether chelerythrine (CHT) exhibited antifungal activity against Candida albicans in vitro and in vivo and to explore the underlying mechanisms.
Ying Gong, Siwen Li, Weixin Wang, Yiman Li, W. Ma, Shujuan Sun   +5 more
semanticscholar   +1 more source

Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine

FEMS Microbiology Letters, 1994
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae, chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient ...
V, Krivjanský, M, Obernauerová, J, Ulrichová, V, Simánek, J, Subík   +4 more
openaire   +2 more sources

Chelerythrine ameliorates acute cardiac allograft rejection in mice

Transplant Immunology, 2016
The improvement in graft survival over the past decade has been mainly due to calcineurin inhibitors, which interfere with the calcium-mediated pathway. Recently, other pathways such as those mediated by protein kinase C (PKC) are coming into view. The purpose of this study was to assess the immunosuppressive properties of chelerythrine, a specific PKC
Qiyi, Zhang, Yang, Tian, Jixuan, Duan, Jingjin, Wu, Sheng, Yan, Hui, Chen, Xueqin, Meng, Kwabena Gyabaah, Owusu-Ansah, Shusen, Zheng   +8 more
openaire   +2 more sources

Evaluation the binding of chelerythrine, a potentially harmful toxin, with bovine serum albumin.

Food and Chemical Toxicology, 2019
Chelerythrine (CHE), a benzophenanthridine alkaloid, is usually used as a nutritional and functional additive in variety of health foods. However, it should be paid enough attention because of its potential toxicity to human health.
Yizhong Shen, Chunlei Zhu, Yaping Wang, Jing-Juan Xu, Ruyu Xue, Fuyun Ji, Yiwei Wu, Zeyu Wu, Wencheng Zhang, Zhi Zheng, Y. Ye   +10 more
semanticscholar   +1 more source