Results 31 to 40 of about 198,073 (289)

Additional file 4 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 4: Figure S3. Enriched pathways across different feature importance cutoffs for RF using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Toxicology Reports, 2019
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI).
Ajay C Donepudi, Michael J. Goedken, John D. Schuetz, José E Manautou   +3 more
doaj   +1 more source

PROSPECTIVE MONITORING OF DRUG USE: DRUG-INDUCED LIVER INJURY IN A PRIMARY HEALTHCARE CENTER [PDF]

Arquivos de Gastroenterologia, 2019
BACKGROUND: Drug-induced liver injury is still misunderstood in Brazil due to diagnostic difficulties or lack of reporting incidents. OBJECTIVE: To assess the frequency of adverse events related to the use of medicines in a primary healthcare unit, in
Nília Maria de Brito Lima PRADO, Gladistone Correia MESSIAS, Genário Oliveira SANTOS JUNIOR, Vinícius Santos NUNES, Maria Isabel SCHINONNI, Raymundo PARANÁ   +5 more
doaj   +1 more source

Additional file 8 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 8: TableS3. Pathways with high feature importance in RF and SVM, and links to DILI. The overrepresented gene sets for 19 proteins with the highest feature importance in RF or SVM models are shown. Many pathways identified possess known functions in liver drug metabolism and cell stress.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]

, 2018
Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core   +1 more source

Additional file 5 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 5: Figure S4. Enriched pathways across different feature importance cutoffs for SVM using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Additional file 7 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 7: TableS2. Proteins with high feature importance in RF and SVM, and links to DILI. The 19 proteins with the highest feature importance in RF or SVM models are shown. The feature importance is shown in bold if the protein ranked among the top 19 in the respective model.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Acute Hepatitis Associated with Intake of Pistacia Vera L. Bud Tea; a Case Report

Archives of Academic Emergency Medicine, 2023
In this study, a patient who developed acute hepatitis due to drinking Pistacia vera L. bud tea is presented. A twenty-eight-year-old woman who had just come out of the postpartum period applied to our clinic with complaints of nausea, vomiting, loss of
Kazım Ersin Altınsoy, Mehmet Murat Oktay   +1 more
doaj   +1 more source

Additional file 6 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 6: Table S1. Performance of models trained using the DILIrank (−vLessConcern) dataset. Shown is mean ± standard deviation for 7 metrics (MCC - Matthew’s Correlation Coefficient, PRAUC - Precision-Recall Area Under Curve, ROCAUC - Receiver-Operator-Characteristic Area Under Curve) for models trained using ECFP4, Mordred molecular ...
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]

, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S., Eghbal, M.A., Sattari, M.R., Taziki, S.   +3 more
core   +1 more source