Results 21 to 30 of about 198,073 (289)

HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE [PDF]

Arquivos de Gastroenterologia, 2019
BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes.
Izabela Rangel LIMA, Ivanise Brito SILVA, Roberta M Leite LIMA, Tainá M Santos SILVA, Maria B Sousa MAIA, Sônia Pereira LEITE   +5 more
doaj   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome

Critical Care, 2022
Background A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine. Simultaneously, an increased
Pedro David Wendel-Garcia, Rolf Erlebach, Daniel Andrea Hofmaenner, Giovanni Camen, Reto Andreas Schuepbach, Christoph Jüngst, Beat Müllhaupt, Jan Bartussek, Philipp Karl Buehler, Rea Andermatt, Sascha David   +10 more
doaj   +1 more source

Carnitine in Alleviation of Complications Caused by Acute Valproic Acid Toxicity; an Exprimental Study on Mice

Archives of Academic Emergency Medicine, 2023
Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice ...
Akram Jamshidzadeh, Reza Heidari, Mahdie Shams, Melika Ebrahimi-sharghi, Sayed Mahdi Marashi   +4 more
doaj   +1 more source

DNA Hydroxymethylation at the Interface of the Environment and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide.
Besaratinia, Ahmad, Tommasi, Stella
core   +1 more source

Definition of the Chemical and Immunological Signals Involved in Drug-Induced Liver Injury

Chemical Research in Toxicology, 2019
Idiosyncratic drug-induced liver injury (iDILI), which is rare and often recognized only late in drug development, poses a major public health concern and impediment to drug development due to its high rate of morbidity and mortality. The mechanisms of DILI are not completely understood; both non-immune- and immune-mediated mechanisms have been ...
Serat-E Ali, James C. Waddington, B. Kevin Park, Xiaoli Meng   +3 more
openaire   +2 more sources

Pharmacological correction of hepatotoxicity induced by anti-tuberculosis drugs

Лечащий Врач, 2023
Drug-induced liver injury are one of the most frequent undesirable effects of drug therapy in tuberculosis patients. Hepatoprotective drugs of various origin and chemical composition are used for the correction and prevention of drug-induced liver injury.
D. S. Sukhanov, E. V. Timofeev, Y. S. Alekseeva, K. A. Nagornova   +3 more
doaj   +1 more source

Relevance of Pharmacogenomics to the Safe Use of Antimicrobials

Antibiotics, 2023
There has been widespread implementation of pharmacogenomic testing to inform drug prescribing in medical specialties such as oncology and cardiology. Progress in using pharmacogenomic tests when prescribing antimicrobials has been more limited, though a
Ann K. Daly
doaj   +1 more source

Application of a Rat Liver Drug Bioactivation Transcriptional Response Assay Early in Drug Development That Informs Chemically Reactive Metabolite Formation and Potential for Drug-induced Liver Injury [PDF]

Toxicological Sciences, 2020
Abstract Drug-induced liver injury is a major reason for drug candidate attrition from development, denied commercialization, market withdrawal, and restricted prescribing of pharmaceuticals. The metabolic bioactivation of drugs to chemically reactive metabolites (CRMs) contribute to liver-associated adverse drug reactions in humans that
Monroe, James J, Tanis, Keith Q, Podtelezhnikov, Alexei A, Nguyen, Truyen, Machotka, Sam V, Lynch, Donna, Evers, Raymond, Palamanda, Jairam, Miller, Randy R, Pippert, Todd, Cabalu, Tamara D, Johnson, Timothy E, Aslamkhan, Amy G, Kang, Wen, Tamburino, Alex M, Mitra, Kaushik, Agrawal, Nancy G B, Sistare, Frank D   +17 more
openaire   +2 more sources

In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]

, 2015
Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana, Feng, Xuli, Kim, Hyun, Lee, Kunwoo, Lingampalli, Nithya, Lo Sterzo, Carlo, Murthy, Niren, Rafi, Mohammad, Tang, Richard, Wang, Xiaojian   +9 more
core   +3 more sources