Results 91 to 100 of about 226,393 (319)

Chemical abundances of stars with brown-dwarf companions

, 2014
It is well-known that stars with giant planets are on average more metal-rich than stars without giant planets, whereas stars with detected low-mass planets do not need to be metal-rich.
Hernández, J. I. González, Israelian, G., Sahlmann, J., Santos, N. C., Sánchez, D. Mata, Udry, S.   +5 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Volatiles and refratories in solar analogs: no terrestial planet connection

, 2010
We have analysed very high-quality HARPS and UVES spectra of 95 solar analogs, 24 hosting planets and 71 without detected planets, to search for any possible signature of terrestial planets in the chemical abundances of volatile and refractory elements ...
Elisa Delgado-Mena, Garik Israelian, Jonay I. González Hernández, Neves, Nuno C. Santos, Ramírez, Ramírez, Sergio Sousa, Sousa, Stéphane Udry, Vasco Neves   +10 more
core   +1 more source

Chemical fractionation and abundances in coronal plasma [PDF]

Advances in Space Research, 2003
10 pages, 4 figures, to appear in Adv.Sp ...
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Abundances in Damped Ly-alpha Galaxies

, 2005
Damped Ly_alpha galaxies provide a sample of young galaxies where chemical abundances can be derived throughout the whole universe with an accuracy comparable to that for the local universe.
A. Chie, G. Israelian, J. Prochaska, P. Molaro   +3 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Chemical Abundances in Star-Forming Galaxies at High Redshift

, 2009
A galaxy's metallicity provides a record of star formation, gas accretion, and gas outflow, and is therefore one of the most informative measurements that can be made at high redshift. It is also one of the most difficult. I review methods of determining
Dawn K. Erb, Edmunds, Halliday, Lequeux, Mehlert   +4 more
core   +1 more source

Chemical abundances in the damped Lyα systems [PDF]

SPIE Proceedings, 2000
14 pages, 7 figures; a refereed review paper to appear in Carnegie Observatories Astrophysics Series, Vol. 4: Origin and Evolution of the Elements, ed. A. McWilliam & M. Rauch (Cambridge: Cambridge Univ. Press)
openaire   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source