Results 121 to 130 of about 226,393 (319)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Chemical Doppelgangers in GALAH DR3: The Distinguishing Power of Neutron-capture Elements among Milky Way Disk Stars

The Astrophysical Journal
The observed chemical diversity of Milky Way stars places important constraints on Galactic chemical evolution and the mixing processes that operate within the interstellar medium. Recent works have found that the chemical diversity of disk stars is low.
Catherine Manea, Keith Hawkins, Melissa K. Ness, Sven Buder, Sarah L. Martell, Daniel B. Zucker   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

High precision differential abundance measurements in globular clusters: chemical inhomogeneities in NGC 6752★ [PDF]

, 2013
David Yong, J. Meléndez, F. Grundahl, Ian U. Roederer, John E. Norris, A. P. Milone, A. F. Marino, P. Coelho, B. McArthur, K. Lind, R. Collet, M. Asplund   +11 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

New Neutral–Neutral Pathways in the Chemistry of Silicon- and Sulfur-bearing Molecules in the Cold Interstellar Medium

The Astrophysical Journal
Silicon is the most abundant third-row element in space and plays a major role in interstellar dust as silicate particles. Furthermore, silicon is important for the formation of silicate dust in oxygen-rich AGB stars and in supernova remnants.
Samuel F. M. Costa, Márcio O. Alves, Sérgio Pilling, Jing Li, Breno R. L. Galvão   +4 more
doaj   +1 more source

Chemical Abundance Signature of J0023+0307: A Second-generation Main-sequence Star with [Fe/H] < −6* [PDF]

, 2019
Anna Frebel, Alexander P. Ji, Rana Ezzeddine, Terese T. Hansen, Anirudh Chiti, Ian B. Thompson, Thibault Merle   +6 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Complete Survey of r-process Conditions: The (Un)robustness of the r-process(es)

The Astrophysical Journal
Heavy elements are synthesized by the r -process in neutron star mergers and potentially in rare supernovae linked to strong magnetic fields. Expensive hydrodynamic simulations of these extreme environments are usually postprocessed to calculate the ...
Jan Kuske, Almudena Arcones, Moritz Reichert   +2 more
doaj   +1 more source

Relation between chemical indices of soil and earthworm abundance under chemical fertilization [PDF]

, 2010
M. Iordache, I. Borza
openalex   +1 more source