Results 181 to 190 of about 198,073 (289)

Comparison and Characteristics of MASLD Mouse Models. [PDF]

Biomedicines
Wei L, Gao C, Qin H.
europepmc   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Picroside II as a Potential Anti-Inflammatory Agent. [PDF]

Pharmaceutics
Ren Y, Liu Z, Wei L, Wang Y, Wang Y, Guo Y, Ma Z.   +6 more
europepmc   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Editor Profiles: Guest Editors of Special Column on Drug- and Chemical-Induced Liver Injury

Acta Pharmaceutica Sinica B, 2021
doaj   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Hepatoprotective Effect of Ethanolic Extract of Cnestis ferruginea Roots on Carbon tetrachloride-Induced Liver Damage in Male Rats

Journal of Applied Sciences and Environmental Management
Hepatoprotection or antihepatotoxicity is the ability of an agent or chemical to prevent damage to the liver. These hepatoprotective agents mitigate the liver injury caused by the hepatotoxic agents.
E. O. Okoro
doaj  

Crosstalk between autophagy and ferroptosis in liver diseases (Review). [PDF]

Int J Mol Med
Wei Y, Zhou K, Su Y, Luan Z, Li P, Chang Y, Han B, Li H, Qiao Y, Ren J.   +9 more
europepmc   +1 more source

Local intratracheal delivery of perfluorocarbon nanoparticles to lung cancer demonstrated with magnetic resonance multimodal imaging [PDF]

, 2018
Chen, Junjie, Lanza, Gregory M, Schmieder, Anne H, Shen, Baozhong, Stacy, Allen J, Sun, Xilin, Wang, Chunan, Wang, Kai, Wang, Xiance, Wen, Xiaofei, Williams, Todd, Wu, Lina, Zhang, Huiying   +12 more
core   +2 more sources

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source