Results 41 to 50 of about 104,898 (118)

Integrated biomarker analysis of multi-organ effects following MDMA and alcohol co-consumption in Pakistan: A pilot study

Toxicology Reports
3,4-Methylenedioxymethamphetamine (MDMA, ''Ecstasy'') is a widely abused recreational drug associated with multi-organ toxicity. Objective was to compare hepatic, renal, and systemic biochemical abnormalities after acute MDMA exposure alone and with ...
Anila Jaleel, Mahnoor Khan, Kiran Namoos, Muhammad Waleed Ibrahim, Junaid Majid Sheikh, Tahira Naseem, Shahila Jaleel, Ghulam Farid   +7 more
doaj   +1 more source

Machine learning-assisted analysis of serum metabolomics for identifying biomarkers in intrinsic and idiosyncratic drug-induced liver injury

Frontiers in Pharmacology
ObjectiveThis project aims to employ high-performance chemical isotope labeling (HP-CIL) liquid chromatography–mass spectrometry (LC-MS) to conduct a metabolomic study on the mechanisms underlying intrinsic and idiosyncratic drug-induced liver injury ...
Xianni Wei, Jinbao Wei, Yuhong Huang, Siheng Lian   +3 more
doaj   +1 more source

Editor Profiles: Guest Editors of Special Column on Drug- and Chemical-Induced Liver Injury

Acta Pharmaceutica Sinica B, 2021
doaj   +1 more source

Hepatoprotective Effects of Curcumin and Thymoquinone Against Chemically Induced Liver Injury: A Schematic Study with Meta-Analysis of Antioxidant and Anti-inflammatory Outcomes

Pakistan Journal of Medicine and Dentistry
Background: Curcumin and thymoquinone are phytochemicals that have shown the ability to protect the liver in previous studies, with involvement of their antioxidant and anti-inflammatory activity. This study aimed to examine the effective concentrations
Madiha Niamat, Mohammad Abid, Abdul Rehman Khalil Shaikh, Sana Masood, Fiza   +4 more
doaj   +1 more source

Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1‑Methyl‑d‑Tryptophan or Acetaminophen

ACS Omega, 2021
Tiffany Cho, Lie Yun Kok, Jack Uetrecht
doaj   +1 more source

Drug-induced liver injury in children: A nationwide cohort study from China

JHEP Reports
Background & Aims: Currently, there is limited knowledge on the clinical profile of drug-induced liver injury (DILI) in Chinese children. We aimed to assess the clinical characteristics, suspected drugs, and outcomes associated with pediatric DILI in
Rongtao Lai, Xinjie Li, Jie Zhang, Jun Chen, Changqing Yang, Wen Xie, Yuecheng Yu, Xiaoyan Guo, Xinrong Zhang, Guoliang Lu, Xi’an Han, Qing Xie, Chengwei Chen, Tao Shen, Yimin Mao   +14 more
doaj   +1 more source

Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state

Scientific Reports
Chronic liver injury induces fibrosis that often proceeds to cirrhosis and hepatocellular carcinoma, indicating that prevention and/or resolution of fibrosis is a promising therapeutic target.
Yasuhiro Nakano, Eiko Saijou, Tohru Itoh, Minoru Tanaka, Atsushi Miyajima, Taketomo Kido   +5 more
doaj   +1 more source

Antioxidant and hepatoprotective effect of Jatropha dioica against the valproic acid-induced damage in an in vivo model

BMC Complementary Medicine and Therapies
Background Understanding liver diseases is important worldwide due to their prevalence. Apart from liver disease arising from hepatitis C viral infection, most chronic liver diseases currently have no cure.
Paula Cordero-Pérez, Ramiro Tijerina-Márquez, Veronica Mayela Rivas-Galindo, Liliana Torres-González, Diana Raquel Rodríguez-Rodríguez, Oscar Humberto Mendoza-Hernández, César Bigran Espinosa-Cantú, Guadalupe Yazmín Solís-Cruz, Linda E. Muñoz-Espinosa, Edelmiro Pérez-Rodríguez, Idalia Cura-Esquivel, Gabriela Alarcón-Galván, Diana Patricia Moreno-Pena   +12 more
doaj   +1 more source

Predicting Drug-Induced Liver Injury Using Convolutional Neural Network and Molecular Fingerprint-Embedded Features

ACS Omega, 2020
Thanh-Hoang Nguyen-Vo, Loc Nguyen, Nguyet Do, Phuc H. Le, Thien-Ngan Nguyen, Binh P. Nguyen, Ly Le   +6 more
doaj   +1 more source

Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury. [PDF]

Elife
Zhu Y, Deng C, Chen B, He J, Liu Y, Lei S, Lu W, Peng C, Shan Z.   +8 more
europepmc   +1 more source