Results 41 to 50 of about 105,032 (245)

Additional file 3 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 3: Figure S2. DILI label prediction performance (balanced accuracy) of RF and SVM models trained using the DILIrank (−vLessConcern) dataset and protein target descriptors for 5-fold LOCO-CV, external test set, and FDA validation set (Methods).
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Toxicology Reports, 2019
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI).
Ajay C Donepudi, Michael J. Goedken, John D. Schuetz, José E Manautou   +3 more
doaj   +1 more source

Role of chemical structures and the 1331T>C bile salt export pump polymorphism in idiosyncratic drug‐induced liver injury

Liver International, 2013
AbstractBackground & AimsSeveral pharmaceutical compounds have been shown to exert inhibitory effects on the bile salt export pump (BSEP) encoded by the ABCB11 gene. We analysed the combined effect on drug‐induced liver injury (DILI) development of the ABCB11 1331T>C polymorphism and the presence of specific chemical moieties, with known BSEP ...
Ulzurrun, Eugenia, Stephens, Camilla, Crespo, Esperanza, Ruiz-Cabello, Francisco, Ruiz-Nuñez, Julia, Saenz-López, Pablo, Moreno-Herrera, Inmaculada, Robles-Díaz, María Mercedes, Hallal, Hacibe, Moreno-Planas, José María, Cabello-Porras, María Rosario, Lucena-González, María Isabel, Andrade-Bellido, Raúl Jesús   +12 more
openaire   +4 more sources

Additional file 9 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 9: TableS4. Top significant structural alerts (p-value ≤0.05). The following quality metrics are shown: precision, coverage in DILI positive compounds (%), and number of Drugbank [44] approved compounds with the substructure are shown.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

A General Overview of Mesenchymal Stem Cell Therapies in Drug- and Chemical-Induced Liver Injury Models

Gazi Medical Journal
Liver injury is commonly seen in the population depending on the drug and chemical usage. Different groups of drugs and chemicals lead to different pathogeneses in the liver, such as necrosis, fibrosis, or inflammation.
Müşerref Şeyma Ceyhan, Suna Ömeroğlu, Zeynep Yığman   +2 more
doaj   +1 more source

Treatment with gefitinib after erlotinib-induced liver injury: a case report

Journal of Medical Case Reports, 2011
Introduction Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver
Nakatomi Katsumi, Nakamura Yoichi, Tetsuya Iida, Kohno Shigeru   +3 more
doaj   +1 more source

Carnitine in Alleviation of Complications Caused by Acute Valproic Acid Toxicity; an Exprimental Study on Mice

Archives of Academic Emergency Medicine, 2023
Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice ...
Akram Jamshidzadeh, Reza Heidari, Mahdie Shams, Melika Ebrahimi-sharghi, Sayed Mahdi Marashi   +4 more
doaj   +1 more source

Relevance of Pharmacogenomics to the Safe Use of Antimicrobials

Antibiotics, 2023
There has been widespread implementation of pharmacogenomic testing to inform drug prescribing in medical specialties such as oncology and cardiology. Progress in using pharmacogenomic tests when prescribing antimicrobials has been more limited, though a
Ann K. Daly
doaj   +1 more source

iDILI-MT: identifying drug-induced liver injury compounds with a multi-head Transformer [PDF]

PeerJ Computer Science
Drug-induced liver injury (DILI) is a leading cause of late-stage drug attrition and post-approval withdrawals, making early in silico risk assessment essential for drug safety.
Wanrong Zheng, Fobao Lai
doaj   +2 more sources

PROSPECTIVE MONITORING OF DRUG USE: DRUG-INDUCED LIVER INJURY IN A PRIMARY HEALTHCARE CENTER [PDF]

Arquivos de Gastroenterologia, 2019
BACKGROUND: Drug-induced liver injury is still misunderstood in Brazil due to diagnostic difficulties or lack of reporting incidents. OBJECTIVE: To assess the frequency of adverse events related to the use of medicines in a primary healthcare unit, in
Nília Maria de Brito Lima PRADO, Gladistone Correia MESSIAS, Genário Oliveira SANTOS JUNIOR, Vinícius Santos NUNES, Maria Isabel SCHINONNI, Raymundo PARANÁ   +5 more
doaj   +1 more source