Results 51 to 60 of about 92,867 (160)

Towards Decoding Hepatotoxicity of Approved Drugs through Navigation of Multiverse and Consensus Chemical Spaces

Biomolecules, 2023
Drug-induced liver injury (DILI) is the principal reason for failure in developing drug candidates. It is the most common reason to withdraw from the market after a drug has been approved for clinical use.
Edgar López-López, José L. Medina-Franco   +1 more
doaj   +1 more source

Pantoprazole-Induced Liver Injury in the Setting of Diabetic Ketoacidosis

Acta Médica Portuguesa
N/a.
Raquel Oliveira, Manuel Almeida, Pedro Lavado, Alexandre Baptista   +3 more
doaj   +1 more source

Drug and herb-induced liver injury: A critical review of Brazilian cases with proposals for the improvement of causality assessment using RUCAM

Annals of Hepatology, 2019
Introduction and Objectives: Although hepatotoxicity accounts for 10% of adverse drug reactions, it remains poorly understood and underreported. This study aimed to summarize case reports of herb- and drug-induced liver injury in Brazil.
Matheus William Becker, Michele John Muller Lunardelli, Cristiane Valle Tovo, Carine Raquel Blatt   +3 more
doaj   +1 more source

Comprehensive characterization of natural products of Polygonum multiflorum by cheminformatics analysis

Pharmacological Research - Modern Chinese Medicine, 2023
Introduction: A growing body of evidence has suggested that Polygonum multiflorum Thunb. (PM) may cause PM-herb-induced liver injury (PM-HILI). However, the compounds triggering PM-HILI remain controversial.
Xiaowen Hu, Tingting Du, Zhao Wang, Feng Wei, Hua Chen, Shuangcheng Ma   +5 more
doaj   +1 more source

Analysis of risk factors of liver injury after intravenous methylprednisolone in neuromyelitis optica spectrum disorders

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the risk factors of liver injury in patients with neuromyelitis optica spectrum disorders (NMOSDs) after intravenous methylprednisolone (IVMP).
YANG Qing⁃lin , LIU Peng⁃peng, WANG Jia⁃wei   +2 more
doaj   +1 more source

Circulating liver-specific miR-122 as a novel potential biomarker for diagnosis of cholestatic liver injury. [PDF]

PLoS ONE, 2013
BACKGROUND: Circulating microRNA-122 (miR-122) has been increasingly reported to be a potential biomarker for drug-, viral-, alcohol- and chemical-induced liver injury.
Huang Shifeng, Wang Danni, Chen Pu, Yang Ping, Cao Ju, Zhang Liping   +5 more
doaj   +1 more source

Additional file 1 of Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction

, 2021
Additional file 1 Supplementary materials for “Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction”
Lesiński, Wojciech, Mnich, Krzysztof, Golińska, Agnieszka Kitlas, Rudnicki, Witold R.   +3 more
openaire   +1 more source

Drug-Induced Hepatitis Caused by Methylphenidate: A Case Report

Acta Médica Portuguesa
Methylphenidate (MPH) is a widely prescribed psychostimulant for the management of attention deficit hyperactivity disorder (ADHD). Although most adverse effects of MPH are transient and reversible, hepatotoxicity remains a rare but potentially serious ...
Diana Valbom Gonçalves, Mariana Bravo, Sónia Almeida, Sandra Ferreira, Sandra Rebimbas   +4 more
doaj   +1 more source

The clinical impact of drug-induced hepatotoxicity on anti-tuberculosis therapy: a case control study

Respiratory Research, 2019
Background There are limited data available on whether drug-induced hepatotoxicity (DIH) affects the clinical outcomes of tuberculosis (TB) treatment. We explored the effects of DIH on the clinical course and outcomes of pulmonary TB.
Jin Hwa Song, Seo-Young Yoon, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung, Jung-Kyu Lee   +6 more
doaj   +1 more source

iDILI-MT: identifying drug-induced liver injury compounds with a multi-head Transformer [PDF]

PeerJ Computer Science
Drug-induced liver injury (DILI) is a leading cause of late-stage drug attrition and post-approval withdrawals, making early in silico risk assessment essential for drug safety.
Wanrong Zheng, Fobao Lai
doaj   +2 more sources