Results 51 to 60 of about 2,835,752 (355)

Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress [PDF]

, 2015
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with ...
Antonilli, Letizia, Badiani, Aldo, Grassi, Maria Caterina, Graziani, Manuela, Saso, Luciano, Togna, Anna Rita   +5 more
core   +8 more sources

Consensus: guidelines: best practices for detection, assessment and management of suspected acute drug-induced liver injury during clinical trials in patients with nonalcoholic steatohepatitis [PDF]

, 2019
BACKGROUND: The last decade has seen a rapid growth in the number of clinical trials enrolling patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH).
Adams, Aithal, Andrade, Angulo, Armstrong, Arroyo, Athyros, Avigan, Banderas, Bays, Belfort, Bjornsson, Caldwell, Chalasani, Chalasani, Chalasani, Chalasani, Chalasani, Chalasani, Chalasani, Cusi, De Denus, De Santis, Dutta, Eijgenraam, Ekstedt, Ekstedt, European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO), Fontana, Friedman, Friedman, Giannini, Guha, Hayashi, Hoofnagle, Hyysalo, Im, Jalan, Kaplan, Kleiner, Kleiner, Kolwankar, Kowdley, Kullak-Ublick, Kwok, LaBrecque, Lavine, Lewis, Lewis, Liddle, Lo Re, Loomba, Maurice, McPherson, Moylan, Mudaliar, Neuschwander-Tetri, Panteghini, Pantsari, Patel, Patel, Pfeffer, Ratziu, Ratziu, Regev, Reid, Robles-Diaz, Rockstroh, Russo, Sanyal, Sanyal, Sanyal, Scorletti, Senior, Siddiqui, Stefan, Tarantino, Temple, Valenti, Verna, Vilar-Gomez, Vuppalanchi, Vuppalanchi, Vuppalanchi, Watkins, Weltman, Wong, Younossi, Younossi, Zelber-Sagi, Zhou, Zimmerman   +91 more
core   +1 more source

Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation

Biology, 2023
Simple Summary Allergic, inflammatory, or autoimmune diseases are characterized by exaggerated immune responses to harmless proteins such as pollen, dust mites, and foods in the environment or self-proteins.
Eri Sakamoto, Yasuhiro Katahira, Izuru Mizoguchi, Aruma Watanabe, Yuma Furusaka, Ami Sekine, Miu Yamagishi, Jukito Sonoda, Satomi Miyakawa, S. Inoue, H. Hasegawa, K. Yo, Fumiya Yamaji, Akemi Toyoda, T. Yoshimoto   +14 more
semanticscholar   +1 more source

A series of homeopathic remedies-related severe drug-induced liver injury from South India

Hepatology Communications, 2023
Introduction: Homeopathic remedies are highly diluted formulations without proven clinical benefits, traditionally believed not to cause adverse events.
A. H. Theruvath, R. Raveendran, C. Philips, R. Ahamed, Jinsha K Abduljaleel, A. Tharakan, S. Rajesh, P. Augustine   +7 more
semanticscholar   +1 more source

A Biochemical Logic Approach to Biomarker-Activated Drug Release [PDF]

J. Mater. Chem. 22, 19709-19717 (2012), 2013
The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---biomarkers for liver injury---were logically processed by a biocatalytic cascade realizing Boolean AND gate. Citrate produced in the system was used to trigger a drug-mimicking
arxiv   +1 more source

Chemistry-Based Modeling on Phenotype-Based Drug-Induced Liver Injury Annotation: From Public to Proprietary Data

Chemical Research in Toxicology, 2023
Drug-induced liver injury (DILI) is an important safety concern and a major reason to remove a drug from the market. Advancements in recent machine learning methods have led to a wide range of in silico models for DILI predictive methods based on ...
M. Moein, Markus Heinonen, N. Mesens, R. Chamanza, C. Amuzie, Y. Will, Hugo Ceulemans, Samuel Kaski, Dorota Herman   +8 more
semanticscholar   +1 more source

Novel bead-based platform for direct detection of unlabelled nucleic acids through Single Nucleobase Labelling [PDF]

, 2016
Over the last decade, circulating microRNAs have received attention as diagnostic and prognostic biomarkers. In particular, microRNA122 has been demonstrated to be an early and more sensitive indicator of drug-induced liver injury than the widely used ...
Ambros, Angelini, Antoine, Arata, Bahal, Barbara López-Longarela, Bartel, Bertoli, Bienenmann-Ploum, Blenkiron, Bowler, Bowler, Campuzano, Cheng, Dear, Ding, Espinosa, Etheridge, Francisco Javier López-Delgado, Geiss, Glushakova, Guo, Hamza, He, Hugh Ilyine, Jin, Jones, Juan José Díaz-Mochón, Kang, Kia, Kilic, Kuhn, Laopa, Lee, Madhavan, Maria Angélica Luque-González, Mario Antonio Fara, Mark Bradley, Mavys Tabraue-Chávez, McCrae, Oom, Patel, Pernagallo, Pham, Price, Rosario María Sánchez-Martín, Sacui, Salvatore Pernagallo, Seitz, Seshasailam Venkateswaran, Socher, Starkey Lewis, Tricoli, Ueno, Velu, Victoria Cano-Cortes, Vliegenthart, Wang, Yang, Zhang   +59 more
core   +1 more source

Idiosyncratic Drug-Induced Liver Injury: From Pathogenesis to Risk Reduction

Safety and Risk of Pharmacotherapy, 2023
Idiosyncratic drug-induced liver injury (iDILI) is a rare and poorly predictable adverse drug reaction that may lead to death or liver transplantation in severe cases.The aim of the study was to review contemporary concepts of the immune-mediated ...
I. A. Mazerkina
semanticscholar   +1 more source

Quantitative Kinetic Models from Intravital Microcopy: A Case Study Using Hepatic Transport [PDF]

The Journal of Physical Chemistry B, 2019, 2019
The liver performs critical physiological functions, including metabolizing and removing substances, such as toxins and drugs, from the bloodstream. Hepatotoxicity itself is intimately linked to abnormal hepatic transport and hepatotoxicity remains the primary reason drugs in development fail and approved drugs are withdrawn from the market.
arxiv   +1 more source

A four-month gatifloxacin-containing regimen for treating tuberculosis. [PDF]

, 2014
BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin ...
Amukoye, Evans, Bah, Boubacar, de Jong, Bouke C, Fielding, Katherine, Gninafon, Martin, Horton, John, Kassa, Ferdinand, Lapujade, Olivier, Lienhardt, Christian, Lo, Mame B, Merle, Corinne S, Mthiyane, Thuli, N'Diaye, Alimatou, Odhiambo, Joseph, OFLOTUB/Gatifloxacin for Tuberculosis Project, Olliaro, Piero L, Perronne, Christian, Rustomjee, Roxana, Sismanidis, Charalambos, Sow, Omou Bah   +19 more
core   +1 more source