Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases Via Haptenation
Biology, 2023 Simple Summary Allergic, inflammatory, or autoimmune diseases are characterized by exaggerated immune responses to harmless proteins such as pollen, dust mites, and foods in the environment or self-proteins.
Eri Sakamoto +14 more
semanticscholar +1 more source
A series of homeopathic remedies-related severe drug-induced liver injury from South India
Hepatology Communications, 2023 Introduction: Homeopathic remedies are highly diluted formulations without proven clinical benefits, traditionally believed not to cause adverse events.
A. Theruvath +7 more
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Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
core +1 more source
Attenuation of ischemic liver injury by prostaglandin E
, 1998 Background: Prostaglandin has been reported to have protective effects against liver injury. Use of this agent in clinical settings, however, is limited because of drugrelated side effects.
Ishizaki, N +8 more
core +1 more source
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data
Chemical Research in ToxicologyDrug-induced liver injury (DILI) has been a significant challenge in drug discovery, often leading to clinical trial failures and necessitating drug withdrawals.
Srijit Seal +6 more
semanticscholar +2 more sources
Chemical and biochemical aspects of drug-induced liver injury [PDF]
, 2011 Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing stage, and is a key cause of drug attrition.
openaire +1 more source
Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study [PDF]
, 2017 Background Radix Bupleuri (RB) has been popularly used for treating many liver diseases such as chronic hepatic inflammation and viral Hepatitis in China.
Huang, Youyi +7 more
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Intravital Multiphoton Microscopy with Fluorescent Bile Salts in Rats as an In Vivo Biomarker for Hepatobiliary Transport Inhibition [PDF]
, 2018 The bile salt export pump (BSEP) is expressed at the canalicular domain of hepatocytes, where it mediates the elimination of monovalent bile salts into the bile.
Chen, Yuan +5 more
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, 2021 Additional file 8: TableS3. Pathways with high feature importance in RF and SVM, and links to DILI. The overrepresented gene sets for 19 proteins with the highest feature importance in RF or SVM models are shown. Many pathways identified possess known functions in liver drug metabolism and cell stress.
Liu, Anika +7 more
openaire +2 more sources
Chemical Research in Toxicology, 2023 Drug-induced liver injury (DILI) is an important safety concern and a major reason to remove a drug from the market. Advancements in recent machine learning methods have led to a wide range of in silico models for DILI predictive methods based on ...
M. Moein +8 more
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