Results 61 to 70 of about 2,835,752 (355)
Chemical and biochemical aspects of drug-induced liver injury [PDF]
, 2011 Adverse drug reactions (ADRs) are a major obstacle for the development of new medicines. They are also a leading cause of patient morbidity and mortality. Although ADRs affect many different organs and bodily systems, drug induced liver injury has lead to the withdrawal of several drugs at the post licensing stage, and is a key cause of drug attrition.
openaire +1 more source
Biomolecules, 2023 Drug-induced liver injury (DILI) is the principal reason for failure in developing drug candidates. It is the most common reason to withdraw from the market after a drug has been approved for clinical use.
Edgar López-López +1 more
doaj +1 more source
, 2021 Additional file 8: TableS3. Pathways with high feature importance in RF and SVM, and links to DILI. The overrepresented gene sets for 19 proteins with the highest feature importance in RF or SVM models are shown. Many pathways identified possess known functions in liver drug metabolism and cell stress.
Liu, Anika +7 more
openaire +2 more sources
Fluorescent probe for the imaging of superoxide and peroxynitrite during drug-induced liver injury†
Chemical Science, 2021 Drug-induced liver injury (DILI) is an important cause of potentially fatal liver disease. Herein, we report the development of a molecular probe (LW-OTf) for the detection and imaging of two biomarkers involved in DILI.
Luling Wu +7 more
semanticscholar +1 more source
Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data
Chemical Research in ToxicologyDrug-induced liver injury (DILI) has been a significant challenge in drug discovery, often leading to clinical trial failures and necessitating drug withdrawals.
Srijit Seal +6 more
semanticscholar +2 more sources
Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report- [PDF]
Anesthesia and Pain MedicineBackground Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use ...
Moon Ok Lee +3 more
doaj +1 more source
Inhibition of Drug‐Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA
Hepatology Communications, 2021 Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents such as DNA during necrosis induces a severe inflammatory response that has yet to be fully explored therapeutically ...
Pedro E. Marques +15 more
doaj +1 more source
, 2021 Additional file 4: Figure S3. Enriched pathways across different feature importance cutoffs for RF using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika +7 more
openaire +2 more sources
Hyperbolic Molecular Representation Learning for Drug Repositioning [PDF]
arXiv, 2022 Learning accurate drug representations is essential for task such as computational drug repositioning. A drug hierarchy is a valuable source that encodes knowledge of relations among drugs in a tree-like structure where drugs that act on the same organs, treat the same disease, or bind to the same biological target are grouped together.
arxiv
, 2021 Additional file 5: Figure S4. Enriched pathways across different feature importance cutoffs for SVM using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika +7 more
openaire +2 more sources