Results 61 to 70 of about 210,019 (338)

Cytoprotective effects of melatonin against amitriptyline-induced toxicity in isolated rat hepatocytes [PDF]

, 2015
Purpose: Amitriptyline, one of the commonly used tricyclic antidepressants, caused rare but severe hepatotoxicity in patients who received it continuously. Previous findings showed that the intermediate metabolites of amitriptyline produced by CYP450 are
Dastmalchi, S., Eghbal, M.A., Sattari, M.R., Taziki, S.   +3 more
core   +1 more source

Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report- [PDF]

Anesthesia and Pain Medicine
Background Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use ...
Moon Ok Lee, Seonghyeon Cho, Chaeeun Kim, Hanna Koh   +3 more
doaj   +1 more source

Additional file 4 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 4: Figure S3. Enriched pathways across different feature importance cutoffs for RF using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Idiosyncratic Drug-Induced Liver Injury: From Pathogenesis to Risk Reduction

Safety and Risk of Pharmacotherapy, 2023
Idiosyncratic drug-induced liver injury (iDILI) is a rare and poorly predictable adverse drug reaction that may lead to death or liver transplantation in severe cases.The aim of the study was to review contemporary concepts of the immune-mediated ...
I. A. Mazerkina
semanticscholar   +1 more source

A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]

, 2009
Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn, A. L. Gerbes, A. M. Vollmar, C. Coester, F. Hoffmann, G. Sass, G. Tiegs, G. Winter, J. Wagner, J. Zillies, S. Fuchs, S. Zahler   +11 more
core   +1 more source

Additional file 5 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 5: Figure S4. Enriched pathways across different feature importance cutoffs for SVM using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Synthesis, in vitro and in vivo evaluation of 3β-[18F]fluorocholic acid for the detection of drug-induced cholestasis in mice [PDF]

, 2017
Introduction : Drug-induced cholestasis is a liver disorder that might be caused by interference of drugs with the hepatobiliary bile acid transporters. It is important to identify this interference early on in drug development.
De Lombaerde, Stef, De Vos, Filip, Devisscher, Lindsey, Kersemans, Ken, Neyt, Sara, Van Vlierberghe, Hans, Vanhove, Christian, Verhoeven, Jeroen   +7 more
core   +3 more sources

Additional file 1 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 1: SI. Overview of gene expression data preparation, DILI model generation, and DILI label prediction performance for models derived using L1000 gene expression data. Gene expression data for 14 distinct cell line-time-dose combinations was extracted for all compounds with DILI labels.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Drug-induced liver injury associated to red yeast rice.

Revista Espanola de Enfermedades Digestivas, 2023
Hepatotoxicity is defined as a liver injury induced by a drug or a non-pharmacological agent like herbal medications or dietary supplements. Red yeast rice is rich in monacolin K, which has the same chemical structure as lovastatin, reason why it has ...
María Desirée García-García, F. Bellido Muñoz, P. Cordero Ruíz, Á. Caunedo Álvarez   +3 more
semanticscholar   +1 more source

Inhibition of Drug‐Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA

Hepatology Communications, 2021
Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents such as DNA during necrosis induces a severe inflammatory response that has yet to be fully explored therapeutically ...
Pedro E. Marques, Sofie Vandendriessche, Thiago H.C. deOliveira, Helena Crijns, Mateus E. Lopes, Marfa Blanter, Sara Schuermans, Karen Yu, Fariba Poosti, Vincent Vanheule, Rik Janssens, Daiane Boff, Andreas J. Kungl, Gustavo B. Menezes, Mauro M. Teixeira, Paul Proost   +15 more
doaj   +1 more source