Results 111 to 120 of about 80,786 (151)

Mechanisms of chemical carcinogenesis

Cancer, 1981
Of the known carcinogenic agents (viruses, ultraviolet and ionizing radiations, and chemicals), chemicals appear to be of major importance in the induction of human cancers. The known chemical carcinogens include a wide range of structures. Their common feature is that their ultimate forms are electrophilic reactants; in most cases, these reactants ...
E C, Miller, J A, Miller
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Environmental and chemical carcinogenesis

Seminars in Cancer Biology, 2004
People are continuously exposed exogenously to varying amounts of chemicals that have been shown to have carcinogenic or mutagenic properties in experimental systems. Exposure can occur exogenously when these agents are present in food, air or water, and also endogenously when they are products of metabolism or pathophysiologic states such as ...
Gerald N, Wogan, Stephen S, Hecht, James S, Felton, Allan H, Conney, Lawrence A, Loeb   +4 more
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Chemical Carcinogenesis in Fishes

2008
Among the industrialized nations of the world, the potential for causing human cancers has been a great concern in risk assessments of environmental pollutants for many years. In contrast, this concern has historically occupied a lower level of interest among those evaluating the risk of chemical hazards to wildlife, including fishes.
Jeanette Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, G.K. Ostrander   +4 more
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The pharmacogenetics of chemical carcinogenesis

Pharmacogenetics, 1992
The human body is endowed with a large number of xenobiotic chemical metabolizing enzymes, a significant proportion of which are polymorphic and thus render one individual at greater or lesser risk than another of chemically-induced disease. All examples of genetic polymorphism of chemical metabolizing enzymes have been reviewed in relation to their ...
Idle, J. R., Armstrong, M., Boddy, A. V., Boustead, C., Cholerton, S., Cooper, J., Daly, A. K., Ellis, Gregory, W., Hadidi, H., Hofer, Holt, Leathart, McCracken, N., Monkman, S. C., Painter, J. E., Taber, Walker, D., Yule   +31 more
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Skin chemical carcinogenesis

Clinics in Dermatology, 1989
Abstract The purpose of this review is to update clinical dermatologists about current concepts of chemical carcinogenesis in skin. The incidence of skin cancer is increasing steadily and it has been estimated that of all new cancers diagnosed annually in the United States, almost one third originate in the skin.
H, Mukhtar, H F, Merk, M, Athar
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Chemical carcinogenesis and the pancreas

Journal of Surgical Oncology, 1975
AbstractAlthough carcinoma of the pancreas is an increasingly prevalent form of human cancer, there has been relatively little experimental work on the etiology of this tumor until recently, probably because of the lack of adequate experimental models. However, at least two good experimental systems are now available.
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Apoptosis and Chemical Carcinogenesis

Risk Analysis, 1994
Long recognized as a normal component of organogenesis during development, apoptosis (programmed cell death) has recently been implicated in alterations of cell growth and differentiation. Tissue homeostasis is normally maintained by a balance between cell division and cell death, with apoptosis often functioning in complement to cell growth.
D S, Marsman, J C, Barrett
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Thresholds in Chemical Carcinogenesis

Regulatory Toxicology and Pharmacology, 1995
It is common practice to base carcinogenic risk assessment on the view that there is no threshold for chemical carcinogenesis. In this context, the threshold is defined as a dose below which no effects are observed. Analysis of epidemiological and experimental data on chemical carcinogenesis confirms that no thresholds have been demonstrated in human ...
I F, Purchase, T R, Auton
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ENVIRONMENTAL CHEMICAL CARCINOGENESIS

Medical Journal of Australia, 1978
The methodology of revealing and studying chemical carcinogens in the environment is based on epidemiology, animal testing, and short-term laboratory studies. The techniques and limitations of these respective investigations are described. From evidence of carcinogenicity, extrapolation must be made to assess whether a particular substance is a cause ...
B W, Stewart, G A, Sarfaty
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Mechanisms of Chemical Carcinogenesis

Annual Review of Pharmacology and Toxicology, 1978
Despite the seemingly disparate endpoints, there are similarities between many drugs and chemical carcinogens when viewed from the basis of pharmacological or toxicological principles. Various biochemical reactions or metabolic pathways of chemical carcinogens are the same as those of other xenobiotics.
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