Results 161 to 170 of about 5,905,748 (198)

Chemical Carcinogenesis in Fishes

2008
Among the industrialized nations of the world, the potential for causing human cancers has been a great concern in risk assessments of environmental pollutants for many years. In contrast, this concern has historically occupied a lower level of interest among those evaluating the risk of chemical hazards to wildlife, including fishes.
Jeanette Rotchell, M.R. Miller, D.E. Hinton, R.T. Di Giulio, G.K. Ostrander   +4 more
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Apoptosis and Chemical Carcinogenesis

Risk Analysis, 1994
Long recognized as a normal component of organogenesis during development, apoptosis (programmed cell death) has recently been implicated in alterations of cell growth and differentiation. Tissue homeostasis is normally maintained by a balance between cell division and cell death, with apoptosis often functioning in complement to cell growth.
D S, Marsman, J C, Barrett
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Thresholds in Chemical Carcinogenesis

Regulatory Toxicology and Pharmacology, 1995
It is common practice to base carcinogenic risk assessment on the view that there is no threshold for chemical carcinogenesis. In this context, the threshold is defined as a dose below which no effects are observed. Analysis of epidemiological and experimental data on chemical carcinogenesis confirms that no thresholds have been demonstrated in human ...
I F, Purchase, T R, Auton
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ENVIRONMENTAL CHEMICAL CARCINOGENESIS

Medical Journal of Australia, 1978
The methodology of revealing and studying chemical carcinogens in the environment is based on epidemiology, animal testing, and short-term laboratory studies. The techniques and limitations of these respective investigations are described. From evidence of carcinogenicity, extrapolation must be made to assess whether a particular substance is a cause ...
B W, Stewart, G A, Sarfaty
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Chemical carcinogenesis and the pancreas

Journal of Surgical Oncology, 1975
AbstractAlthough carcinoma of the pancreas is an increasingly prevalent form of human cancer, there has been relatively little experimental work on the etiology of this tumor until recently, probably because of the lack of adequate experimental models. However, at least two good experimental systems are now available.
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The pharmacogenetics of chemical carcinogenesis

Pharmacogenetics, 1992
The human body is endowed with a large number of xenobiotic chemical metabolizing enzymes, a significant proportion of which are polymorphic and thus render one individual at greater or lesser risk than another of chemically-induced disease. All examples of genetic polymorphism of chemical metabolizing enzymes have been reviewed in relation to their ...
Idle, J. R., Armstrong, M., Boddy, A. V., Boustead, C., Cholerton, S., Cooper, J., Daly, A. K., Ellis, Gregory, W., Hadidi, H., Hofer, Holt, Leathart, McCracken, N., Monkman, S. C., Painter, J. E., Taber, Walker, D., Yule   +31 more
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Mechanisms of Chemical Carcinogenesis

Annual Review of Pharmacology and Toxicology, 1978
Despite the seemingly disparate endpoints, there are similarities between many drugs and chemical carcinogens when viewed from the basis of pharmacological or toxicological principles. Various biochemical reactions or metabolic pathways of chemical carcinogens are the same as those of other xenobiotics.
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Cutaneous chemical carcinogenesis

Journal of the American Academy of Dermatology, 1986
This review is designed to inform the clinician of current concepts regarding the pathogenesis of chemically induced skin cancer. Chemicals induce cutaneous cancers in a wide variety of experimental animals and in humans. The most common benign experimental tumors are papillomas and keratoacanthomas, whereas common malignancies are squamous cell ...
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Carcinogenesis: Chemical and Otherwise

Radiation Research, 1972
A review is made not only of the kinds of chemicals which are carcinogenic, but a suggestion is also given about one of the characteristics which may belong to the cells which are chemically transformed. This characteristic has already been shown to be associated with neoplastic cells produced by oncogenic viruses and constitutes the presence of a ...
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Inhibitors of Chemical Carcinogenesis

1978
Publisher Summary Chemical carcinogens play a very significant role in the etiology of cancer in man. This chapter describes a number of compounds that have the capacity to inhibit the neoplastic effects of chemical carcinogens when administered either prior to exposure to the carcinogen or at the same time.
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