Results 61 to 70 of about 176,623 (273)

Cadmium-associated molecular pathways drive gender-specific pathogenesis and prognosis in lung adenocarcinoma

Ecotoxicology and Environmental Safety
Lung adenocarcinoma (LUAD) demonstrates pronounced female predominance and escalating incidence, yet sex-specific environmental determinants remain poorly characterized.
Yusi Yang, Zhiyuan Zhang, Xing He, Zhiya Li, Lin Lu, Yiguo Jiang, Yueting Shao   +6 more
doaj   +1 more source

Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients

Frontiers in Pharmacology, 2019
Testicular cancer is one of the most commonly occurring malignant tumors in young men with fourfold higher rate of incidence and threefold higher mortality rates in Chile than the average global rates.
María A. Lavanderos, Juan P. Cayún, Ángela Roco, Ángela Roco, Christopher Sandoval, Leslie Cerpa, Juan C. Rubilar, Roberto Cerro, Sebastián Molina-Mellico, Cesar Celedón, Berta Cerda, Elena García-Martín, José A. G. Agúndez, Cristián Acevedo, Cristián Acevedo, Karina Peña, Dante D. Cáceres, Dante D. Cáceres, Nelson M. Varela, Luis A. Quiñones   +19 more
doaj   +1 more source

Pyrimido[1,2-a]-purin-10(3H)-one, M(1)G, is less prone to artifact than base oxidation [PDF]

, 2005
Pyrimido[1,2-a]-purin-10(3H)-one (M(1)G) is a secondary DNA damage product arising from primary reactive oxygen species (ROS) damage to membrane lipids or deoxyribose.
Jeong, Yo-Chan, Nakamura, Jun, Swenberg, James A., Upton, Patricia B.   +3 more
core   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Thiram Effects on HeLa TI Cells

Proceedings
Dithiocarbamate pesticides possess a diverse array of molecular mechanisms, making them multifunctional substances [...]
Varvara Maksimova, Anzhelika Bukina, Guzel Khayrieva, Valeriia Popova, Marianna Yakubovskaya, Kirill Kirsanov   +5 more
doaj   +1 more source

Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components

Journal of the Formosan Medical Association, 2016
Betel quid (BQ) chewing is popular in Taiwan and many other countries. There are about 200–600 million BQ chewers in the world. BQ chewing is one major risk factor of oral cancer and oral submucous fibrosis (OSF).
Chien-Yang Yeh, Hsin-Ming Chen, Mei-Chi Chang, Seng-Heng Kok, Jang-Jaer Lee, Bei-En Chang, Po-Yuan Jeng, Chiu-Po Chan, Jiiang-Huei Jeng   +8 more
doaj   +1 more source

Long-term cultivation of two diploid epithelial cell lines derived from normal rat liver cells [PDF]

, 1974
To obtain a useful rat liver cell line for in vitro carcinogenesis, two rat diploid epithelial cell lines were established from a 7-day-old male rat by the repeated colonial clone method.
Masuji, Hiroshi, Nakabayashi, Hidekazu, Sato, Jiro   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Cyclooxygenase-2 Expression in Hamster and Human Pancreatic Neoplasia

Neoplasia: An International Journal for Oncology Research, 2006
Cyclooxygenase-2 (COX-2) has been implicated in the development of gastrointestinal malignancies. The aim of the present study was to determine COX-2 expression/activity throughout stages of experimental and human pancreatic neoplasia.
Pamela L. Crowell, C. Max Schmidt, Michele T. Yip-Schneider, Jesse J. Savage, Dean A. Hertzler, II, William O. Cummings   +5 more
doaj   +1 more source