Results 151 to 160 of about 3,897,550 (347)

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Inertial mixing of acoustically levitated droplets for time‐lapse protein crystallography

Droplet
Varying the chemical consistency of acoustically levitated droplets opens up an in situ study of chemical and biochemical reactions in small volumes. However, the optimization of the mixing time and the minimization of the positional instability induced ...
Soichiro Tsujino, Yohei Sato, Shichao Jia, Michal W. Kepa, Sofia Trampari, Takashi Tomizaki   +5 more
doaj   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

The Crystal Structure and Physicochemical Properties of New Complexes Containing a Cu^II-Ln^III-Cu^II Core

Crystals
Three new cationic complexes, [Cu4Tb2(H2L)4(NO3)4(H2O)3](NO3)2·5.5H2O·2MeOH (1), [Cu4Ho2(H2L)4(NO3)4(H2O)3](NO3)2·7.5H2O (2), and [Cu4Er2(H2 L)4(NO3)4(H2O)3](NO3)2·7H2O·3MeOH (3), were synthesized and studied using elemental and TG/DTG/DSC analyses ...
Beata Cristóvão, Dariusz Osypiuk, Barbara Mirosław   +2 more
doaj   +1 more source

The new chemical crystallography beamline at PETRA III [PDF]

, 2018
Martin Tolkiehn
openalex   +1 more source

Dynamic three-dimensional structures of a metal–organic framework captured with femtosecond serial crystallography

Nature Chemistry
Crystalline systems consisting of small-molecule building blocks have emerged as promising materials with diverse applications. It is of great importance to characterize not only their static structures but also the conversion of their structures in ...
Jaedong Kang, Yunbeom Lee, Seonggon Lee, H. Ki, Jungmin Kim, J. Gu, Yongjun Cha, Jun Heo, Kyung Won Lee, Seong Ok Kim, Jaehyun Park, Sang-Youn Park, Sangsoo Kim, Rory Ma, I. Eom, Minseok Kim, Jeongho Kim, Jae Hyuk Lee, H. Ihee   +18 more
semanticscholar   +1 more source

Atomic‐Scale Insights into Yttrium‐Induced Grain Boundary Structure Modification in Al2O3

Advanced Science, EarlyView.
Using advanced STEM characterization combined with NNP‐based MCMD calculations, it is revealed that Y segregation at ∑13 Al2O3 GB involves not only simple substitution of Y for Al atoms but also structural adaptation with a change in GB atomic density, leading to minimized excess volume and lowest GB energy.
Jingyuan Yan, Tatsuya Yokoi, Yuuki Nakano, Shun Kondo, Bin Feng, Naoya Shibata, Katsuyuki Matsunaga, Yuichi Ikuhara   +7 more
wiley   +1 more source

Coordination Polymers of Vanadium and Selected Metal Ions with N,O-Donor Schiff Base Ligands—Synthesis, Crystal Structure, and Application

Molecules
This review provides an overview of the synthesis, characterization and application of coordination polymers based on N,O-donor Schiff base ligands.
Dariusz Osypiuk, Agata Bartyzel, Beata Cristóvão   +2 more
doaj   +1 more source

A Quest for the Mechanism of Ultrahigh Resolution SEM Imaging

Advanced Science, EarlyView.
Using Monte Carlo simulations with explicit definitions of SE1 and SE2 align with a cascade secondary electron production model, this work shows that the 3D nanostructure modulated SE2 emission enhances other than to reduce topographical contrast via a “miniature Faraday cup” effect.
Hao Tian Chen, Y.B. Zou, B. Da, Z.J. Ding   +3 more
wiley   +1 more source

Exploration of Ruthenium(II/III/VI)–Salen Complexes: From Synthesis to Functional Applications

Molecules
This review provides a comprehensive overview of recent advances in the synthesis, structural characterization, and applications of Ru(II), Ru(III), and Ru(VI) complexes, which bear tetradentate Schiff bases of salen type.
Beata Cristóvão, Dariusz Osypiuk, Agata Bartyzel   +2 more
doaj   +1 more source