Results 111 to 120 of about 1,572,221 (316)

Is Life an Unavoidable Consequence of the Formation of the Universe? Investigating the Formation of Bio-Precursors and the Signature of Earth-Like Living Forms

Frontiers in Astronomy and Space Sciences, 2018
This contribution to the Research Topic “Imagining the Future of Astronomy and Space Sciences” focuses on astrobiology and exoplanetary research. Understanding the origin of life is the main scientific challenge to this century and an interdisciplinary ...
Ana I. Gomez de Castro
doaj   +1 more source

Hydro- Chemical Evolution of Palk Strait Region, Bay of Bengal [PDF]

, 2012
Present analysis was carried out the physico- chemical parameters of two stations such as Thondi and Soliyakudi in the southeast Palk Strait region during the monsoon and post monsoon seasons (November 2008 – March 2009).
Arulpriya, M. (Mani), govindasamy, C. (chinavenkataraman), Meenakshi, V. R. (V), Ruban, P. (Packiasamy)   +3 more
core  

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Stellar Yields and Chemical Evolution [PDF]

Symposium - International Astronomical Union, 2002
Several speakers at this symposium have alluded to the zeroth-order agreement between the Type II supernovae (SNe) stellar yields, as predicted by the models of those most responsible for driving progress in the field - i.e. Arnett (1991,1996); Maeder (1992); Woosley & Weaver (1995); Langer & Henkel (1995); Thielemann et al.
openaire   +4 more sources

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Discharge plasma for prebiotic chemistry: Pathways to life’s building blocks

Earth and Planetary Physics
Discharge plasmas, recognized as unique platforms for investigating the origins of chemical life, have garnered extensive interest for their potential to simulate prebiotic conditions. This paper embarks on a comprehensive overview of recent advancements
DingWei Gan, LongFei Hong, TianYu Li, TianQi Zhang, XiangYu Wang, JiePing Fan, RuSen Zhou, DingXin Liu, JianXi Ying, Patrick J. Cullen, YuFen Zhao, RenWu Zhou   +11 more
doaj   +1 more source

On the origin of fluorine in the Milky Way

, 2004
The main astrophysical factories of fluorine (19F) are thought to be Type II supernovae, Wolf-Rayet stars, and the asymptotic giant branch (AGB) of intermediate mass stars.
Agostino Renda, Alessandro Chieffi, Alibés, Allende Prieto, Amanda I. Karakas, Bekki, Bertelli, Brad K. Gibson, Cappellaro, Cunha, Dray, Fenner, Forestini, Frost, Frost, Gibson, Holweger, Iglesias, Iwamoto, John C. Lattanzio, Jorissen, Karakas, Karakas, Katia Cunha, Kroupa, Limongi, Lugaro, Meynet, Mowlavi, Myra, Rana, Renzini, Russell, Schaller, Simon Campbell, Smith, Timmes, Vassiliadis, Verne V. Smith, Woosley, Woosley, Woosley, Woosley, Yeshe Fenner   +43 more
core   +2 more sources

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Chemical Evolution of CNO Abundances [PDF]

, 2003
New low and intermediate star yields calculated by Buell (1997) are evaluated by using them in a Galactic Chemical Evolution model.
Mercedes Mollá, M. Gavilán
openaire   +3 more sources