Results 51 to 60 of about 1,572,221 (316)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Frontiers in Nuclear EngineeringLong time frames are to be considered in the safety and performance assessment of deep geological disposal of intermediate and high level radioactive waste.
Guido Deissmann +2 more
doaj +1 more source
Frontiers in Microbiology, 2021 The possible evolutionary significance of pyrophosphate (PPi) has been discussed since the early 1960s. Lipmann suggested that PPi could have been an ancient currency or a possible environmental source of metabolic energy at origins, while Kornberg ...
Jessica L. E. Wimmer +2 more
doaj +1 more source
Chemical Evolution Tomorrow [PDF]
, 2002 The solar system is just one sample, though of course the most thoroughly studied sample, of cosmic chemistry. Some perspective on it can be gained from an overview of the chemical evolution of the Galaxy and Universe, how our knowledge of this evolution has developed, and what problems remain to be solved.
Virginia Trimble, Virginia Trimble
openaire +3 more sources
Chemical evolution with radial mixing [PDF]
Monthly Notices of the Royal Astronomical Society, 2009 22 pages, 21 figures, 1 table updated to new GCS data release, slightly revised, accepted by ...
Schönrich, R, Binney, J
openaire +7 more sources
`Pure' Supernovae and Accelerated Expansion of the Universe
, 2011 A special class of type Ia supernovae that is not subject to ordinary and additional intragalactic gray absorption and chemical evolution has been identified.
A. Aguirre +26 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
A plausible pathway to prebiotic peptides via amino acid amides on the primordial Earth
Earth and Planetary PhysicsThe prebiotic synthesis of peptides prior to ribosome-catalyzed processes remains an enigma. The synthesis of abiotic peptides from amino acids (AAs) is primarily constrained by high activation energies and unfavorable thermodynamics, necessitating the ...
DingWei Gan +8 more
doaj +1 more source
Molecular Asymmetry in Prebiotic Chemistry: An Account from Meteorites
Life, 2016 Carbonaceous Chondrite (CC) meteorites are fragments of asteroids, solar planetesimals that never became large enough to separate matter by their density, like terrestrial planets.
Sandra Pizzarello
doaj +1 more source
Life, 2022 The role of minerals in the chemical evolution of RNA molecules is an important issue when considering the early stage of the Hadean Earth. In particular, the interaction between functional ribozymes and ancient minerals under simulated primitive ...
Kunio Kawamura +5 more
doaj +1 more source