Results 51 to 60 of about 1,642,984 (314)
Thermodynamics of Potential CHO Metabolites in a Reducing Environment
Life, 2021 How did metabolism arise and evolve? What chemical compounds might be suitable to support and sustain a proto-metabolism before the advent of more complex co-factors? We explore these questions by using first-principles quantum chemistry to calculate the
Jeremy Kua +2 more
doaj +1 more source
On the Galactic chemical evolution of sulphur. Sulphur abundances from the [S i] 1082 nm line in giants [PDF]
, 2013 Context. The Galactic chemical evolution of sulphur is still under debate. At low metallicities some studies find no correlation between [S/Fe] and [Fe/H], others find [S/Fe] increasing towards lower metallicities, and still others find a combination of ...
Dupree, A. K., Matrozis, E., Ryde, N.
core +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
The Mystery of Homochirality on Earth
LifeHomochirality is an obvious feature of life on Earth. On the other hand, extraterrestrial samples contain largely racemic compounds. The same is true for any common organic synthesis.
Michael G. Weller
doaj +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Life, 2022 The origin of life on Earth required myriads of chemical and physical processes. These include the formation of the planet and its geological structures, the formation of the first primitive chemicals, reaction, and assembly of these primitive chemicals ...
Arpita Saha +4 more
doaj +1 more source
The delayed time distribution of massive double compact star mergers
, 2016 In order to investigate the temporal evolution of binary populations in general, double compact star binaries and mergers in particular within a galactic evolution context, a most straightforward method is obviously the implementation of a detailed ...
Mennekens, N., Vanbeveren, D.
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Synthesis and Characterization of Amino Acid Decyl Esters as Early Membranes for the Origins of Life
Membranes, 2022 Understanding how membrane forming amphiphiles are synthesized and aggregate in prebiotic settings is required for understanding the origins of life on Earth 4 billion years ago.
Isabella Lago +3 more
doaj +1 more source
`Pure' Supernovae and Accelerated Expansion of the Universe
, 2011 A special class of type Ia supernovae that is not subject to ordinary and additional intragalactic gray absorption and chemical evolution has been identified.
A. Aguirre +26 more
core +1 more source