Results 71 to 80 of about 5,463,250 (252)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Chemical fractionation of nickel in asphaltite based bottom ash

, 2013
Asphaltite, originating from petroleum, contains many kinds of mineral elements derived from its generation. These elements exist in different forms which may change throughout the asphaltite combustion process.
Hamamci, Candan, Aydin, Firat, Kilinc, Ersin, Aydin, Isil, Duz, M. Zahir   +4 more
core   +1 more source

Empirical evidence for the fractionation of carbon isotopes between diamond and iron carbide from the Earth’s mantle [PDF]

, 2014
S.M. would like to thank the Engineering and Physical Sciences Research Council, the Diamond Trading Company, and the Department of Physical Sciences, The Open University (UK) for financial support during his time as a PhD student at University College ...
Krispin, Catherine, Crispin, K., Jones, A.P., Verchovsky, Alexander, Guillermier, C., Beard, Andrew, Milledge, H.J., Beard, Andy, Verchovsky, A.B., Jones, Adrian, Franchi, I.A., Milledge, H Judith, Mikhail, Sami, Guillermier, Christalle, Mikhail, S., Beard, Andrew D., Franchi, Ian   +16 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Soil Phosphorus Fraction Characteristics in Different Alpine Grassland Types of the Qinghai–Tibet Plateau

Agronomy
The alpine grassland ecosystem of the Tibetan Plateau is a vital base for animal husbandry and a key ecological security barrier in China. Phosphorus (P), an essential nutrient, is among the primary factors limiting grassland productivity.
Xueting Li, Zhan Liu, Cuilan Li, Ning Zong, Nianpeng He, Zhiyuan Cao, Jinjing Zhang   +6 more
doaj   +1 more source

Experimental constraints on kinetic and equilibrium silicon isotope fractionation during the formation of non-biogenic chert deposits [PDF]

, 2015
Silicon isotopic compositions (δ30Si) of modern and ancient siliceous sedimentary rocks provide valuable information on conditions in depositional environments, but interpretations are hampered by the lack of experimentally validated fractionation ...
van Bergen, Manfred J., Vroon, Pieter Z., Petrology, Geilert, Sonja, van den Boorn, Sander H.J.M., Roerdink, Desiree L., van den Boorn, Sander H J M, NWO-ALW Open: Exploring the Earth's earliest oceans with silicon: magnitudes of isotopic fractionation, NWO-NSO: Testing the robustness of the sulfur stable isotope biomarker and paleoredox indicator for planetary exploration   +8 more
core   +2 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Ultra-Micro-Scale-Fractionation (UMSF) as a Powerful Tool for Bioactive Molecules Discovery

Molecules, 2020
Herein is detailed the development and validation of an ultra-micro-scale-fractionation (UMSF) technique for the discovery of plant-based, bioactive molecules, coupling the advantages of ultra-performance liquid chromatography mass spectrometry (UPLC-MS)
Jason L. McCallum, Jennifer N. D. Vacon, Christopher W. Kirby   +2 more
doaj   +1 more source