Results 81 to 90 of about 6,188,412 (297)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Perspective on automated predictive kinetics using estimates derived from large datasets

A longstanding project of the chemical kinetics community is to predict reaction rates and the behavior of reacting systems, even for systems where there are no experimental data.
Green, William H
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Automated reaction kinetics and network exploration (Arkane): A statistical mechanics, thermodynamics, transition state theory, and master equation software

The open-source statistical mechanics software described here, Arkane–Automated Reaction Kinetics and Network Exploration–facilitates computations of thermodynamic properties of chemical species, high-pressure limit reaction rate coefficients, and ...
Merchant, Shamel S, Goldsmith, Franklin, Dana, Alon Grinberg, Buras, Zachary J, Spiekermann, Kevin A, Wu, Haoyang, Johnson, Matthew S, Class, Caleb A, Liu, Mengjie, Gillis, Ryan J, Raman, Sumathy, Grambow, Colin A, Goldman, Mark J, Dames, Enoch E, West, Richard H, Vandewiele, Nick M, Yee, Nathan W, Dong, Xiaorui, Ranasinghe, Duminda S, Payne, A Mark, Buesser, Beat, Li, Yi‐Pei, Allen, Joshua W, Green, William H, Gao, Connie W, Sharma, Sandeep   +25 more
core   +1 more source

Hydrothermally Synthesized ZnCr- and NiCr-Layered Double Hydroxides as Hydrogen Evolution Photocatalysts

Molecules
The layered double hydroxides (LDHs) of transition metals are of great interest as building blocks for the creation of composite photocatalytic materials for hydrogen production, environmental remediation and other applications. However, the synthesis of
Sergei A. Kurnosenko, Oleg I. Silyukov, Ivan A. Rodionov, Anna S. Baeva, Andrei A. Burov, Alina V. Kulagina, Silvestr S. Novikov, Irina A. Zvereva   +7 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Chemical master equation and Langevin regimes for a gene transcription model [PDF]

, 2008
Gene transcription models must take account of intrinsic stochasticity. The Chemical Master Equation framework is based on modelling assumptions that are highly appropriate for this context, and the Stochastic Simulation Algorithm (also known as ...
Higham, Desmond J., Khanin, Raya
core   +2 more sources

A Novel Method of Probing the Fractional Composition of Nanosystems

KONA Powder and Particle Journal, 2014
The article presents a comparison of the traditional methods to investigate the fractional composition of nanosized powders, namely atomic force microscopy (AFM), scanning electron microscopy (SEM), dynamic light ...
Alexander S. Kozlov, Alexandr K. Petrov, Gennady N. Kulipanov, Vladimir O. Aseyev   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Automated chemical resonance generation and structure filtration for kinetic modeling

, 2019
© 2019 Wiley Periodicals, Inc. This work discusses efficient and automated methods for constructing a set of representative resonance structures for arbitrary chemical species, including radicals and biradicals, consisting of the elements H, C, O, N, and
Green, William H., Liu, Mengjie, Grinberg Dana, Alon, Green, William H, Mengjie Liu, Alon Grinberg Dana, William H. Green   +6 more
core   +1 more source