A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Nature CommunicationsThe kagome network is a unique platform that harbors a diversity of special electronic states due to its inherent band structure features comprising Dirac cones, van Hove singularities, and flat bands. Some kagome-based metals have recently been found to
Robin Guehne +6 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To investigate the overall use of prescription medications among individuals with multiple sclerosis compared to the general population, with a focus on treatments beyond disease‐modifying therapies. Methods We conducted a nationwide, registry‐based study in Denmark.
Josefine Windfeld‐Mathiasen +4 more
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The RED scheme: Rate-constant estimation from pre-steady state weighted ensemble simulations. [PDF]
J Chem Phys, 2021 DeGrave AJ, Bogetti AT, Chong LT.
europepmc +1 more source
Chemical Physics in the University of Manchester: Prof. G. Allen [PDF]
, 1965 openalex +1 more source
Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald +74 more
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Informing NMR experiments with molecular dynamics simulations to characterize the dominant activated state of the KcsA ion channel. [PDF]
J Chem Phys, 2021 Pérez-Conesa S +4 more
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Scott: Erwin Schrödinger/Waerden: Erwachende Wissenschaft/Gossick: Hamilton's Principle and Physical Systems/Destouches: Qu'est‐ce que la physique mathématique?/Donovan: The Internat. Encyclopedia of Physical Chemistry and Chemical Physics/Pohl: Elektrizitätslehre/Cremer: Körperschall/Christian: The Theory of Transformations in Metals and Alloys/Davies: The Theory of the Electric and Magnetic Properties of Molecules/Theissing: Spectroscopic Calculations for a Multielectron Ion/Ingram: … [PDF]
, 1968 F. Hund +12 more
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