Results 221 to 230 of about 11,594,512 (293)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Physico-Chemical Properties and Performance of Functional Monomers Used in Contemporary Dental Adhesive Technology. [PDF]

J Adhes Dent
Delgado AHS, Ahmed MH, Nunes Ferreira M, Mano Azul A, Polido M, Yoshihara K, Van Meerbeek B.   +6 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Leveraging quantum chemical properties in transfer learning for predicting blood-brain barrier permeability of drugs. [PDF]

Drug Deliv Transl Res
Lim MA, Yonk MG, Hoang KB, Molinaro AM, Raj M, Du Y, Boulis NM, Hassaneen W, Lei K.   +8 more
europepmc   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Controlled Crystallization Enables Facile Fine-Tuning of Physical-Chemical Properties of Nicergoline Toward Easier Processability. [PDF]

Pharmaceuticals (Basel)
Prudilová BB, Gabriel R, Otyepka M, Otyepková E.   +3 more
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Functional Group Distribution Shapes Chemical Properties of Degraded Terrestrial and Marine Dissolved Organic Matter. [PDF]

Environ Sci Technol
Matos RR, Craig A, Koch BP, Hawkes J, Moodie LWK, Ivanova A, Gleixner G, Guth P, Knorr KH, Tebben J, Reemtsma T, Zherebker A, Lechtenfeld OJ.   +12 more
europepmc   +1 more source

Succinic acid improves crop chemical components by regulating soil chemical properties, microbes and metabolites. [PDF]

Front Microbiol
Li DL, Liu Q, Zhao RJ, Gao WC, Zheng XR, Zhou SY, Cai K, Jiang XJ.   +7 more
europepmc   +1 more source

Multiscale Evaluation of Mechanical, Microstructural, and Chemical Properties of Weathered Aggregates on the Qinghai-Tibet Plateau. [PDF]

Materials (Basel)
Liu H, Li X, Ren H, Zhang X, Shuai Y, Wu X, Bo W.   +6 more
europepmc   +1 more source