Results 41 to 50 of about 134,150 (259)
Missing links as a source of seemingly variable constants in complex reaction networks
Physical Review Research, 2020 A major challenge in network science is to determine parameters governing complex network dynamics from experimental observations and theoretical models.
Zachary G. Nicolaou, Adilson E. Motter
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Efficient multi-fidelity computation of blood coagulation under flow.
PLoS Computational Biology, 2023 Clot formation is a crucial process that prevents bleeding, but can lead to severe disorders when imbalanced. This process is regulated by the coagulation cascade, a biochemical network that controls the enzyme thrombin, which converts soluble fibrinogen
Manuel Guerrero-Hurtado +8 more
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Uncertainty quantification for quantum chemical models of complex reaction networks
Faraday Discussions, 2016 For the quantitative understanding of complex chemical reaction mechanisms, it is, in general, necessary to accurately determine the corresponding free energy surface and to solve the resulting continuous-time reaction rate equations for a continuous state space.
Proppe, Jonny +3 more
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A scalable algorithm to explore the Gibbs energy landscape of genome-scale metabolic networks. [PDF]
PLoS Computational Biology, 2012 The integration of various types of genomic data into predictive models of biological networks is one of the main challenges currently faced by computational biology.
Daniele De Martino +3 more
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Piecewise linear models of chemical reaction networks
, 2012 We show that certain non-linear dynamical systems with non-linearities in the form of Hill functions, can be approximated by piecewise linear dynamical systems. The resulting piecewise systems have closed form solutions that can be used to understand the behavior of the fully nonlinear system.
Kumar, Ajit, Josić, Krešimir
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The modelling and synthesis of chemical reaction networks
, 2020 Biochemical systems have been influenced, altered, and engineered to produce a myriad of complex behaviours that have far reaching consequences in the realization of computational models and in applications such as pharmaceuticals and cell networks.
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
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Modeling the Impact of Moderate External UV Irradiation on Disk Chemistry
The Astrophysical JournalThe chemistry within a protoplanetary disk is greatly affected by external radiation from the local stellar environment. Previous work has focused on extreme radiation fields, representative of the center of something like the Orion Nebula Cluster ...
Rachel E. Gross, L. Ilsedore Cleeves
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Ain Shams Engineering Journal, 2017 The underlying system models of time series prediction are complex and not known a priori, hence, accurate and unbiased estimation cannot be always achieved using well known linear techniques.
S.C. Nayak, B.B. Misra, H.S. Behera
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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