Results 51 to 60 of about 134,150 (259)
Constructing and visualizing chemical reaction networks from pi-calculus models [PDF]
Formal Aspects of Computing, 2013 Abstract The π -calculus, in particular its stochastic version the stochastic π -calculus, is a common modeling formalism to concisely describe the chemical reactions occurring in biochemical systems.
Mathias John +4 more
openaire +4 more sources
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Atmospheric reaction systems as null-models to identify structural traces of evolution in metabolism. [PDF]
PLoS ONE, 2011 The metabolism is the motor behind the biological complexity of an organism. One problem of characterizing its large-scale structure is that it is hard to know what to compare it to. All chemical reaction systems are shaped by the same physics that gives
Petter Holme, Mikael Huss, Sang Hoon Lee
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Thermodynamics of random reaction networks. [PDF]
PLoS ONE, 2015 Reaction networks are useful for analyzing reaction systems occurring in chemistry, systems biology, or Earth system science. Despite the importance of thermodynamic disequilibrium for many of those systems, the general thermodynamic properties of ...
Jakob Fischer +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Disentangling CO Chemistry in a Protoplanetary Disk Using Explanatory Machine-learning Techniques
The Astrophysical JournalMolecular abundances in protoplanetary disks are highly sensitive to the local physical conditions, including gas temperature, gas density, radiation field, and dust properties.
Amina Diop +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The Astronomical JournalThe chemical composition of protoplanetary disks, especially in the molecular layer and above, is set by photoprocesses driven by stellar radiation fields.
Jamila Pegues +5 more
doaj +1 more source
PLoS ONE, 2012 The inference of reaction rate parameters in biochemical network models from time series concentration data is a central task in computational systems biology.
Philipp Kügler
doaj +1 more source