Results 81 to 90 of about 919,666 (317)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Recent Trends in Quantum Chemical Modeling of Enzymatic Reactions
, 2017 The quantum chemical cluster approach is a powerful method for investigating enzymatic reactions. Over the past two decades, a large number of highly diverse systems have been studied and a great wealth of mechanistic insight has been developed using ...
Himo, Fahmi,, Fahmi Himo
core +1 more source
Discovery of Novel Chemical Reactions by Deep Generative Recurrent Neural Network
, 2020 Here, we report an application of Artificial Intelligence techniques to generate novel chemical reactions of the given type. A sequence-to-sequence autoencoder was trained on the USPTO reaction database.
Igor I., Baskin +9 more
core +1 more source
Kernel Methods for Predicting Yields of Chemical Reactions
, 2022 The use of machine learning methods for the prediction of reaction yield is an emerging area. We demonstrate the applicability of support vector regression (SVR) for predicting reaction yields, using combinatorial data.
Taylor, Adam +9 more
core +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Quantum Dynamics Studies of Chemical Reactions: From Triatomic to Polyatomic Systems
, 2009 In this talk, I will present some of our recent work on accurate quantum reactive scattering studies of chemical involving three, four, and six atoms. For tratomic reaction, I will show state-to-stae differential cross sections for the H + O2 and O + O2 ...
张东辉, Dong Hui Zhang
core
Kinetics of Chemical Reactions
, 2023 This course deals with the experimental and theoretical aspects of chemical reaction kinetics, including transition-state theories, molecular beam scattering, classical techniques, quantum and statistical mechanical estimation of rate constants, pressure-
Green Jr., William, Steinfeld, Jeffrey
core
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source