Results 31 to 40 of about 11,492,440 (323)

Pretreatment data is highly predictive of liver chemistry signals in clinical trials

Drug Design, Development and Therapy, 2012
Purpose The goal of this retrospective analysis was to assess how well predictive models could determine which patients would develop liver chemistry signals during clinical trials based on their pretreatment (baseline) information.
Zhaohui J. Cai, Anders Bresell, M. H. Steinberg, D. Silberg, S. Furlong   +4 more
semanticscholar   +1 more source

Practical recommendations for managing hemolyzed samples in clinical chemistry testing

Clinical Chemistry and Laboratory Medicine, 2018
We suggest here a pragmatic approach for managing results of clinical chemistry testing in hemolyzed samples collected from adults/older children, attempting to balance the need to produce quality laboratory data with clinical urgency of releasing test ...
G. Lippi, J. Cadamuro, A. von Meyer, A. Šimundić   +3 more
semanticscholar   +1 more source

New trends for metal complexes with anticancer activity [PDF]

, 2008
Medicinal inorganic chemistry can exploit the unique properties of metal ions for the design of new drugs. This has, for instance, led to the clinical application of chemotherapeutic agents for cancer treatment, such as cisplatin. The use of cisplatin is,
Ang, Ang, Barnard, Barnes, Bednarski, Bergamo, Bregman, Calderone, Casini, Debreczeni, Dixon, Dyson, Failes, Feazell, Guo, Habtemariam, Hall, Hambley, Hannon, Harris, Heringova, Hillard, Hotze, James, Jung, Komeda, Liu, Lutterman, MacDiarmid, Mackay, Mackay, McNae, Meggers, Milacic, Noor, Oleksi, Orvig, Ott, Pascu, Peacock, Peter J Sadler, Pieter CA Bruijnincx, Reed, Schatzschneider, Schlawe, Scolaro, Smalley, Sun, Thompson, Timerbaev, Urig, Urig, van Zutphen, Wang, Weidt, Yan, Yang   +56 more
core   +1 more source

Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications

Pharmaceuticals, 2018
Chemotherapy is one of the major therapeutic options for cancer treatment. Chemotherapy is often associated with a low therapeutic window due to its poor specificity towards tumor cells/tissues.
Nirnoy Dan, S. Setua, Vivek K Kashyap, Sheema S. Khan, M. Jaggi, M. Yallapu, S. Chauhan   +6 more
semanticscholar   +1 more source

Frontiers in Pigment Cell and Melanoma Research

, 2018
We identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current ...
Birlea, Stanca, Bosenberg, Marcus W., Box, Neil F., Brash, Douglas, Cassidy, Pamela B., Chen, Suzie, D'Orazio, John August, Filipp, Fabian V., Fujita, Mayumi, Goh, Boon-Kee, Herlyn, Meenhard, Indra, Arup K., Larue, Lionel, Leachman, Sancy A., Liu-Smith, Feng, Manga, Prashiela, Montoliu, Lluis, Norris, David A., Poole, Caroline Le, Shellman, Yiqun, Smalley, Keiran S. M., Spritz, Richard A., Sturm, Richard A., Swetter, Susan M., Terzian, Tamara, Wakamatsu, Kazumasa, Weber, Jeffrey S.   +26 more
core   +1 more source

Clinical Chemistry through Clinical Chemistry: A Journal Timeline [PDF]

Clinical Chemistry, 2004
Abstract The establishment of the modern discipline of clinical chemistry was concurrent with the foundation of the journal Clinical Chemistry and that of the American Association for Clinical Chemistry in the late 1940s and early 1950s.
openaire   +2 more sources

Human neutrophil lipocalin (HNL) as a biomarker of acute infections

Upsala Journal of Medical Sciences, 2018
The early and accurate discrimination between bacterial and viral causes of acute infections is the key to a better use of antibiotics and will help slow down the fast-growing resistance to commonly used antibiotics.
Per Venge
doaj   +1 more source

Data on interference indices in body fluid specimens submitted for clinical laboratory analysis

Data in Brief, 2020
Clinical chemistry analysis of body fluids from non-blood or urine sources presents a technical challenge for clinical laboratories. Examples of body fluids include biliary secretions, cerebrospinal fluid, cyst contents, dialysate, gastric aspirates ...
Renee L. Eigsti, Matthew D. Krasowski, Aditi Vidholia, Anna E. Merrill   +3 more
doaj   +1 more source

Applying Standard Clinical Chemistry Assay Validation to Droplet Digital PCR Quantitative Liquid Biopsy Testing.

Clinical Chemistry, 2018
BACKGROUND Droplet digital PCR (ddPCR) is an emerging technology for quantitative cell-free DNA oncology applications. However, assay performance criteria must be established in a standardized manner to harness this potential.
D. Milošević, J. Mills, Michael B. Campion, Noemi Vidal-Folch, Jesse S. Voss, K. Halling, W. Highsmith, Minetta C. Liu, B. Kipp, S. Grebe   +9 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source