Results 181 to 190 of about 10,692 (235)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Alcohol Oxidase-Imine Reductase Cascade for One-Pot Chiral Amine Synthesis. [PDF]

ACS Catal
Miletic A, Truby CJ, Turner NJ, Ruscoe RE.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Auxiliary TARP Subunits Define AMPA Receptor Pharmacology and Function. [PDF]

J Xenobiot
Bdir S, Çapan İ, Hawash M, Servi S, Qneibi M.   +4 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Palladium immobilized on CdFe₂O₄ as highly efficient, reusable, and organic-inorganic hybrid catalyst for the synthesis of pyridine derivatives. [PDF]

Discov Nano
Abushuhel M, Zaki MEA, Rekha MM, Basheer NM, Ray S, Pal A, Sharma R, Gomha SM, Singh A.   +8 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Strengthening HIV Programs in Sub-Saharan Africa Through Implementation Research: A Mixed-Methods Systematic Review. [PDF]

AIDS Res Treat
Bwire GM, Nyondo GG, Njiro BJ, Aiko BG, Mikomangwa WP, Manguzu MA, August F, Myemba DT, Magati R, Chillo P, Mugusi F, Bakari M, Sudfeld C, Sangeda RZ, Killewo J.   +14 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Metabolic syndrome among patients with severe mental illness attending a tertiary hospital in northwestern, Tanzania: A cross sectional study. [PDF]

PLOS Ment Health
Msele DR, Kimosso EK, Ghaimo FE, Chacha S, Kilonzo NM, Mwita M, Likindikoki S.   +6 more
europepmc   +1 more source