Results 191 to 200 of about 10,692 (235)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Ratiometric fluorescent sensors based on MXene quantum dots: linking photophysics, architecture, and multi-analyte food detection. [PDF]

RSC Adv
Abu Shuheil M, Mayn Fadl F, Ahmad IA, Shukla MB, M M R, Sharma P, Juma B, Yaxshimuratov M, Mahmoodi S.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Uptake and determinants of Hepatitis B vaccination among health laboratory practitioners in tertiary hospitals in Dar es Salaam, Tanzania: A cross-sectional study. [PDF]

PLOS Glob Public Health
Said S, Migiro M, Renatus D, Gangji RR, Nkinda L, Kibwana U, Msafiri F, Kamori D, Joachim A, Manyahi J, Majigo MV, Masoud SS.   +11 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

MXene quantum dots for geochemical ion sensing: mechanism-driven design of integrated platforms. [PDF]

RSC Adv
Oriquat G, Mohammed Ali MS, Suleman AD, Shukla MB, M M R, Surya CP, Sharma P, Aldulaimi A, Noorizadeh H.   +8 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

<i>AKT2</i> Exon 3 Variants and Their Prevalence in Prostate Cancer Patients: Insights from a Jordanian Clinical Cohort. [PDF]

Int J Mol Sci
Rahahlah N, Al-Alami Z, Alorjani MS, Al-Smadi A, Obeidat S, Otoom R, Al-Zoubi RM, Al Bashir S, Al Zoubi MS.   +8 more
europepmc   +1 more source

Knowledge and Practices on Household Disposal of Unused Antimicrobials in Ho Municipality, Ghana. [PDF]

Int J Environ Res Public Health
Aku TA, Jato J, Atsu LD, Oteng D, Ben IO, Somuah SO, Odoi H, Orman E, Dodoo C, Jani Y, Hutton-Nyameaye AA.   +10 more
europepmc   +1 more source

Presence of Sildenafil and Tadalafil in Herbal Medicinal Products Claimed to Treat Erectile Dysfunction in Nyamagana and Ilemela Districts, Mwanza, Tanzania. [PDF]

Biomed Res Int
Mchallah FJ, Matinde R, Thomas A, Kihwili L, Mafuru T, Kapala J, Kimaro E, Moyo AA, Mutagwaba E, Maregesi SM.   +9 more
europepmc   +1 more source