Results 31 to 40 of about 10,989 (277)

A computational pipeline combining machine learning and molecular simulations identifies repurposed PI3Kα inhibitors from FDA-approved drugs

Artificial Intelligence Chemistry
The computational repurposing of existing drugs has proven to be a fast-track strategy in the development of new cancer therapy. Nonetheless, integrated mechanistically grounded approaches are required for a more reliable in silico identification of new ...
Prince Danan Biniyam, Naomi Kayeri, Seth Junior Ayihi, Syed Arslan Haider, Hope Dzitorwoko, Kwabena Adu-Adjei, Michael Osei, Victoria Ohene-Adu, Portia Frimpong, Clifford Tignangnen Penajah, Silas Boakye Amissah, Nimra Mazhar, Cedric Dzidzor Kodjo Amengor   +12 more
doaj   +1 more source

Single-molecule chemistry studies with engineered alpha-hemolysin pores

, 2011
Engineered protein nanopores can be used to investigate a wide range of dynamic processes in real time and at the single-molecule level, for example covalent bond making and breaking or the interaction of ligands with their cognate binding sites.
Hammerstein, Anne Friederike
core   +1 more source

Antioxidant and Anti-Skin Aging Potential of Selected Thai Plants: In Vitro Evaluation and In Silico Target Prediction

Plants, 2022
The skin is the largest organ that performs a variety of the body’s essential functions. Impairment of skin structure and functions during the aging process might severely impact our health and well-being. Extensive evidence suggests that reactive oxygen
Kamonwan Chaikhong, Sawarin Chumpolphant, Panthakarn Rangsinth, Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab   +6 more
doaj   +1 more source

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Synthesis,characterization and antimicrobial activity of zinc(II)ibuprofen complexes with nitrogen-based ligands

, 2016
Chemistry and Allied Sciences Omar,Suhad: Darwish,Mohanad: Faris ...
Darwish, Mohanad, Suhad N. Omar (1397554), Faris, Hadeel Hassan, Hijazi Abu Ali (1397557), Omar, Suhad Nizar, Hadeel Fares (1397551), Abu Ali, Hijazi, Mohanad D. Darawsheh (1397560)   +7 more
core   +1 more source

Association of Drug-Metabolizing Enzyme and Transporter Gene Polymorphisms and Lipid-Lowering Response to Statins in Thai Patients with Dyslipidemia

Pharmacogenomics and Personalized Medicine, 2022
Natchaya Vanwong,1,2 Sayanit Tipnoppanon,1 Chalitpon Na Nakorn,3 Pornpen Srisawasdi,4 Punyanuch Rodcharoen,4 Sadeep Medhasi,5 Pajaree Chariyavilaskul,2,6,7 Sarawut Siwamogsatham,2,8,9 Yongkasem Vorasettakarnkij,2,9 Chonlaphat Sukasem10– 12 1Department of
Vanwong N, Tipnoppanon S, Na Nakorn C, Srisawasdi P, Rodcharoen P, Medhasi S, Chariyavilaskul P, Siwamogsatham S, Vorasettakarnkij Y, Sukasem C   +9 more
doaj  

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Chemical controls on incipient Mg-silicate crystallisation at 25oC : implications for early and late diagenesis

, 2014
Mg-silicate minerals (e.g., stevensite, kerolite, talc, sepiolite) play an important role in the construction of facies models in lacustrine and peri-marine environments because they are sensitive to changes in solution chemistry.
Tosca, Nick, Masterson, Andrew
core   +1 more source

Thai plants with high antioxidant levels, free radical scavenging activity, anti-tyrosinase and anti-collagenase activity

BMC Complementary and Alternative Medicine, 2017
Background Ultraviolet radiation from sunlight induces overproduction of reactive oxygen species (ROS) resulting in skin photoaging and hyperpigmentation disorders.
Moragot Chatatikun, Anchalee Chiabchalard   +1 more
doaj   +1 more source

Effectiveness of a Novel Low‐Density Lipoprotein Apheresis Device Rheocarna in Patients Undergoing Hemodialysis With Chronic Limb‐Threatening Ischemia: A Single‐Center Retrospective Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic limb‐threatening ischemia (CLTI) is a severe form of lower‐extremity artery disease characterized by distal lesions and microcirculatory impairment, limiting revascularization efficacy. Rheocarna is a direct hemoperfusion low‐density lipoprotein (LDL) adsorption device with potential rheological and anti‐inflammatory ...
Kunihiro Ishioka, Takayasu Ohtake, Kei Ohmori, Chika Shibuya, Tomoki Tsukahara, Mizuki Yamano, Yasuhiro Mochida, Machiko Oka, Kyoko Maesato, Yusuke Tsukamoto, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi   +12 more
wiley   +1 more source