Results 31 to 40 of about 10,692 (235)

Dual-Targeting MDM2 and CDK4: An Integrated Machine Learning and Molecular Simulation Pipeline Identifies Novel Fungal Metabolites for Cancers with Co-Dysregulated p53 and Rb Pathways

In Silico Research in Biomedicine
Resistance to single-target therapies necessitates innovative strategies in oncology, particularly for aggressive cancers characterized by co-dysregulated p53 and Rb pathways.
Prince Danan Biniyam, Dickson Aboagye, Lawrence Kwame Nkrumah, Solomon Sackitey, Jesse Ayim Buabeng, Victoria Ohene-Adu, Kwabena Adu-Adjei, Samuel Klu, Seth Junior Ayihi, Clifford Tignangnen Penajah, Cedric Dzidzor Kodjo Amengor   +10 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The need for a functional pharmaceutical industry in Sierra Leone: lessons from the COVID-19 pandemic

Journal of Pharmaceutical Policy and Practice, 2022
With an estimated population of 8.3 million, Sierra Leone has no existing pharmaceutical manufacturing company at present. The recent COVID-19 pandemic brought to the limelight the fragility and weakness of the Sierra Leonean pharmaceutical industry as ...
Eugene Conteh, Melody Okereke, Foday Umaro Turay, Alhaji Sununu Bah, Abdulwasiu Muhsinah   +4 more
doaj   +1 more source

Neuroprotective Effects against Glutamate-Induced HT-22 Hippocampal Cell Damage and Caenorhabditis elegans Lifespan/Healthspan Enhancing Activity of Auricularia polytricha Mushroom Extracts

Pharmaceuticals, 2021
Oxidative stress is associated with several diseases, particularly neurodegenerative diseases, commonly found in the elderly. The attenuation of oxidative status is one of the alternatives for neuroprotection and anti-aging.
Chanin Sillapachaiyaporn, Panthakarn Rangsinth, Sunita Nilkhet, Alison T. Ung, Siriporn Chuchawankul, Tewin Tencomnao   +5 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

CDK4/6 inhibitors upregulate cIAP1/2, and Smac mimetic LCL161 enhances their antitumor effects in cholangiocarcinoma cells

Scientific Reports
Cholangiocarcinoma (CCA) is a highly aggressive bile duct cancer with a poor prognosis and high mortality rates, primarily due to the lack of early diagnosis and effective treatments.
Pimchanok Menapree, Nattaya Duangthim, Apiwit Sae-Fung, Sasiprapa Sonkaew, Siriporn Jitkaew   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Vitis Vinifera Leaf Extract Protects Against Glutamate-Induced Oxidative Toxicity in HT22 Hippocampal Neuronal Cells and Increases Stress Resistance Properties in Caenorhabditis Elegans

Frontiers in Nutrition, 2021
Vitis vinifea has been used for traditional medicines, food, beverages, and dietary antioxidant supplements. The chemical compositions and biological activities of the fruits and seeds have been extensively investigated.
Chatrawee Duangjan, Chatrawee Duangjan, Chatrawee Duangjan, Panthakarn Rangsinth, Panthakarn Rangsinth, Shaoxiong Zhang, Shaoxiong Zhang, Xiaojie Gu, Xiaojie Gu, Michael Wink, Tewin Tencomnao, Tewin Tencomnao, Tewin Tencomnao   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Antioxidant, Antibacterial Activity, In Silico Molecular Docking, and ADME-Toxicity Study of Lactone from Rhizome of Angiopteris helferiana

Journal of Chemistry
Objective. The red rhizome of Angiopteris helferiana has been used widely to treat muscle fatigue, bone pain, and skin infection in Nepal. However, scientific evidence for its bioactive compounds and their bioactivities was lacking till January, 2024 ...
Ram Kishor Yadav, Priyanka Shrestha, Kalpana Timilsina, Akriti Dhakal, Sandesh Poudel, Sindhu K. C., Prabhat Kumar Jha, Susheel Paneru, Rekha Bhandari, Khem Raj Joshi   +9 more
doaj   +1 more source