Results 91 to 100 of about 721,337 (349)
A critical review of HPLC-based analytical methods for quantification of Linezolid
, 2020 Linezolid is a synthetic antimicrobial agent belonging to the oxazolidinone class. Since its approval in the year 2000 until now, linezolid remains the main representative drug for the oxazolidinone class of drugs, which is used in therapy due to its ...
Salgado, Hérida Regina Nunes [UNESP] +5 more
core +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Emerging Analytical Techniques for Rapid Pathogen Identification and Susceptibility Testing.
Annual Review of Analytical Chemistry, 2019 In the face of looming threats from multi-drug resistant microorganisms, there is a growing need for technologies that will enable rapid identification and drug susceptibility profiling of these pathogens in health care settings.
D. J. Shin +4 more
semanticscholar +1 more source
The application of microwave radiation to analytical and environment chemistry
, 1995 This review presents the latest advances in the application of microwave energy to analytical chemistry. The fundamental principles of microwave field interaction with the matter are presented and their significance for the chemist is discussed, followed
Taylor & Francis
core
Green analytical methods and principles of green analytical chemistry
The chemical field, in previous years, has worked through a linear process, and this type of trend caused large waste volume and accumulation, leading to the current crisis of pollution and the environment.
Samanidou, Victoria F. +6 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Analytical Chemistry Techniques Manual
, 2010 A set of four separate guides which provide introductions to the principles and practical application of different analytical chemistry techniques, illustrated with simple diagrams and photographs of equipment: (1) introduction to analytical chemistry ...
Stephen Summerfield +2 more
core
Analytical methodology for sulfonated lignins
, 2010 There is a significant need to characterize and classify lignins and sulfonated lignins. Lignins have so far received a good deal of attention, whereas this is not true for sulfonated lignins.
Schoenmakers, P., Brudin, S.
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source