Results 101 to 110 of about 9,046,305 (303)
The application of microwave radiation to analytical and environment chemistry
, 1995 This review presents the latest advances in the application of microwave energy to analytical chemistry. The fundamental principles of microwave field interaction with the matter are presented and their significance for the chemist is discussed, followed
Taylor & Francis
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Analytical Chemistry 2.0 [PDF]
, 2010 1. Introduction to Analytical Chemistry2. Basic Tools of Analytical Chemistry3. The Vocabulary of Analytical Chemistry4. Evaluating Analytical Data5. Standardizing Analytical Methods6. Equilibrium Chemistry7. Obtaining and Preparing Samples for Analysis8.
Harvey, David
core +1 more source
Ecological aspects in the teaching of analytical chemistry [PDF]
, 1999 The role of methods of analytical chemistry in environmental analysis and the importance of training specialists with various skills and analytical chemists, first of all, ecologists are discussed. © 1999 MAHK "Hayka/Interperiodica"
Budnikov G.
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source