Results 61 to 70 of about 5,044 (221)

Recent advances in nanomaterial-based drug delivery systems for melanoma therapy [PDF]

, 2023
Background and Purpose Safe and effective drug delivery is crucial for the treatment of cancer, which is quite impossible to achieve through traditional methods.
Jena, Goutam Kumar, Kaishap, Partha Pratim, Parhi, Rabinarayan   +2 more
core   +2 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

H-MnO2 nanoparticles loaded with photosensitizer IR825 target the tumor microenvironment to alleviate hypoxia and synergy therapy

Results in Chemistry
Tumor microenvironment (TME) is characterized by low pH, high hydrogen peroxide (H2O2) concentration and severe hypoxia, which lead to tumor progression, metastasis and drug resistance.
Yunji Sun, Maokun Sun, Xiaolu Sun, Chao Zhang, Jianchao Zhang, Xiaoxiao Zhao, Benkang Shi   +6 more
doaj   +1 more source

Precise Chemodynamic Therapy of Cancer by Trifunctional Bacterium-Based Nanozymes

ACS Nano, 2021
Chemodynamic therapy (CDT) destroys cancer cells by converting H2O2 or O2 into reactive oxygen species (ROS), but its therapeutic efficacy is restricted by the antioxidant capacity of tumor. Previous solutions focused on strengthening the nanodrugs with the ability to increase ROS production or weaken the antioxidant capacity of cancer cells ...
Weiyun Zhang, Jiawei Liu, Xuyu Li, Yue Zheng, Lianfu Chen, Dongdong Wang, Mohamed Frahat Foda, Zhaoyu Ma, Yanli Zhao, Heyou Han   +9 more
openaire   +4 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Design of a two-dimensional interplanar heterojunction for catalytic cancer therapy

Nature Communications, 2022
Chemodynamic therapy relies on Fenton or Fenton-like reactions to produce hydroxyl radical in the tumor region. Here the authors design a two-dimensional interplanar heterojunction with in situ hydroxyl radical generation under ultrasound irradiation ...
Yong Kang, Zhuo Mao, Ying Wang, Chao Pan, Meitong Ou, Hanjie Zhang, Weiwei Zeng, Xiaoyuan Ji   +7 more
doaj   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

In Situ Redox of TiSe2 Nanoplates to Excite Chemodynamic‐Enhanced Cancer Sono‐Immunotherapy

Small Structures
Different from the direct delivery of chemodynamic agents into tumor tissue for chemodynamic therapy (CDT), this work reports the fabrication of heterojunction sonosensitizers (CD/TiSe2) for the in situ generation of chemodynamic agents by responding to ...
Xialing He, Jinming Cai, Jinyan Hu, Zhenlin Zhang, Xue Bai, Shan Zhang, Dengyu Pan, Jinliang Liu, Bijiang Geng   +8 more
doaj   +1 more source

An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy

Nature Communications, 2020
The supply of oxygen species for dynamic therapy is a major limitation. Here, the authors report on a complex of calcium peroxide with photo/chemo dynamic agents, where NIR heating causes the release of calcium peroxide to generate oxygen and hydrogen ...
Conghui Liu, Yu Cao, Yaru Cheng, Dongdong Wang, Tailin Xu, Lei Su, Xueji Zhang, Haifeng Dong   +7 more
doaj   +1 more source

Cooperative coordination-mediated multi-component self-assembly of “all-in-one” nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer

Acta Pharmaceutica Sinica B, 2022
Carrier-free multi-component self-assembled nano-systems have attracted widespread attention owing to their easy preparation, high drug-loading efficiency, and excellent therapeutic efficacy.
Xiaojie Chen, Xudong Fan, Yue Zhang, Yinghui Wei, Hangsheng Zheng, Dandan Bao, Hengwu Xu, Ji-Gang Piao, Fanzhu Li, Hongyue Zheng   +9 more
doaj   +1 more source