Results 81 to 90 of about 6,653 (267)

Synergistic Activation of Immunogenic Cell Death and the cGAS–STING Pathway by Engineered Zinc/Manganese‐Based Metal–Organic Framework Nanoplatforms for Colon Cancer Immunotherapy

Advanced Science, EarlyView.
A zinc/manganese (Zn/Mn)‐based metal‐organic framework (MOF) loaded with the STING agonist c‐di‐AMP diammonium (denoted AMP@Zn/Mn‐MOF) was developed to synergistically activate the cGAS‐STING pathway and induce immunogenic cell death. This nanoplatform reprograms the immunosuppressive tumor microenvironment, significantly enhancing anti‐PD‐L1 ...
Bingzi Zhu, Xiaodong Chen, Chang Xu, Xuehua Qian, Binglong Bai, Ji Lin, Wenhai Deng, Xiang Wang, Yuekai Cui, Shengsheng Zhao, Zuoliang Xie, Tao You, Yingpeng Huang, Xian Shen, Xufeng Lu, Weijian Sun   +15 more
wiley   +1 more source

Self-targeted nanosystem for enhanced chemodynamic cancer therapy

Biomaterials Science
A schematic illustration of ZnNP enhanced CDT for HGSOC. ZnNP promotes the tumor-specific generation of bioactive H2O2, which subsequently triggers ROS-dependent apoptotic cell death.
Kanwal Asif, Md. Mahbubur Rahman, Vincenzo Canzonieri, Isabella Caligiuri, Flavio Rizzolio, Muhammad Adeel   +5 more
openaire   +2 more sources

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

GSH-responsive sequential mitochondria-targeting nanoagents for photothermal-enhanced chemodynamic therapy

Materials & Design, 2022
Mitochondria-targeting nanoparticles have proven to be promising platforms for cancer therapy. However, precise mitochondria targeting in the complex tumor environment is still challenging and requires more ingenious design.
Huaming He, Fang Zhao, Wukun Zhong, Yuling Yang, Yuhong Lin, Yihang Ding, Jiajia Yang, Chunhua Lu, Xiankun Tu   +8 more
doaj   +1 more source

A LDH‐Based Supramolecular Photosensitizer‐Functionalized Bioactive Glass Scaffold for Integrated Postoperative Osteosarcoma Recurrence Prevention and Bone Regeneration

Advanced Science, EarlyView.
An intercalation assembly strategy is proposed to construct a novel LDH‐based supramolecular photosensitizer, which exhibits outstanding reactive oxygen species generation activity under 1270 nm laser irradiation. The deposition of supramolecular photosensitizer onto the surface of bioactive glass scaffolds results in the development of an innovative ...
Tao Wang, Yixin Bian, Tingting Hu, Mengyang Li, Yuqin Tan, Yu Yang, Xiaolan Jian, Xisheng Weng, Chaoliang Tan, Ruizheng Liang   +9 more
wiley   +1 more source

Bibliometric and visualized analysis of metal-organic frameworks in biomedical application

Frontiers in Bioengineering and Biotechnology, 2023
Background: Metal-organic frameworks (MOFs) are hybrid materials composed of metal ions or clusters and organic ligands that spontaneously assemble via coordination bonds to create intramolecular pores, which have recently been widely used in biomedicine
Sanyang Yu, Kaihao Xu, Zhenhua Wang, Zhichang Zhang, Zhongti Zhang   +4 more
doaj   +1 more source

A pH/H₂O₂ Dual-Responsive Cobalt-Manganese-Based Nano-Delivery System for Chemo/Chemodynamic Therapy in Triple-Negative Breast Cancer. [PDF]

Int J Nanomedicine
Mei G, Lin F, Huang L, Lin M, Lin X, Huang L.   +5 more
europepmc   +3 more sources

Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, 2023
AbstractThe emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue to persist. Currently, antibiotic therapy remains the primary approach for tackling bacterial infections. However, the escalating rates of drug resistance coupled with the lag in the development of novel drugs have ...
Junjie Zhang, Haiyang Guo, Ming Liu, Kaiyuan Tang, Shengke Li, Qiang Fang, Hengda Du, Xiaogang Zhou, Xin Lin, Yanjun Yang, Bin Huang, Dongliang Yang   +11 more
openaire   +3 more sources

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Peroxisome inspired hybrid enzyme nanogels for chemodynamic and photodynamic therapy

Nature Communications, 2021
The control of reactive oxygen species in cancer cells is an attractive approach for anticancer applications. Here, the authors create a peroxisome inspired lactate oxidase and catalase loaded hydrogel with iron nanoparticles and NIR photosensitizer for ...
Xing Qin, Chu Wu, Dechao Niu, Limei Qin, Xia Wang, Qigang Wang, Yongsheng Li   +6 more
doaj   +1 more source