Results 71 to 80 of about 2,610 (179)

A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy

Frontiers in Pharmacology, 2022
Chemodynamic therapy (CDT) eradicates tumors by intratumoral catalytic chemical reaction and subsequently disrupts redox homeostasis, which shows tumor specific reactive oxygen species (ROS)-mediated therapy. However, insufficient ROS generation and high
Wenzhao Zhong, Feng Guo, Fangman Chen, Man-Kay Law, Jun Lu, Dan Shao, Hua Yu, Ging Chan, Meiwan Chen   +8 more
doaj   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

H-MnO2 nanoparticles loaded with photosensitizer IR825 target the tumor microenvironment to alleviate hypoxia and synergy therapy

Results in Chemistry
Tumor microenvironment (TME) is characterized by low pH, high hydrogen peroxide (H2O2) concentration and severe hypoxia, which lead to tumor progression, metastasis and drug resistance.
Yunji Sun, Maokun Sun, Xiaolu Sun, Chao Zhang, Jianchao Zhang, Xiaoxiao Zhao, Benkang Shi   +6 more
doaj   +1 more source

Key Modulation of ROS and HSP for Effective Therapy Against Hypoxic Tumor with Multifunctional Nanosystem

International Journal of Nanomedicine, 2023
Bangzhen Ma,1,2 Yisheng Zhao,3 Xiaoli Liu,4 Mengping Huo,2 Jinghong Wang,2 Jiwei Ma,2 Yang Zhang,2 Chengkun Qin1,2 1Shandong Provincial Hospital, Shandong University, Jinan, Shandong, 250021, People’s Republic of China; 2Shandong Provincial Hospital ...
Ma B, Zhao Y, Liu X, Huo M, Wang J, Ma J, Zhang Y, Qin C   +7 more
doaj  

Interfacial Chemistry‐Tailored Silica&Metal‐Based Heterostructures: from Rational Design to Antibacterial Applications

Small, EarlyView.
This review explores how interfacial engineering of silica&metal‐based nanohybrids enables precise architectural control, leveraging the structural and functional contributions of silica to overcome the inherent limitations of meta‐based materials. The antibacterial performance of these nanohybrids including membrane disruption, stimuli‐responsive ...
Dan Cheng, Yuchao Gu, Chengzhong Yu
wiley   +1 more source

Dual-targeting nanozyme for tumor activatable photo-chemodynamic theranostics

Journal of Nanobiotechnology, 2022
Tumor phototheranostics holds a great promise on account of its high spatiotemporal resolution, tumor-specificity, and noninvasiveness. However, physical limitation of light penetration and “always on” properties of conventional photothermal-conversion ...
Chaoyi Chen, Yuwen Chen, Lulu Zhang, Xuanhao Wang, Qingshuang Tang, Yan Luo, Yuan Wang, Cheng Ma, Xiaolong Liang   +8 more
doaj   +1 more source

External Stimuli‐Activable Single‐Atom Nanozymes for Bioapplications

Small, EarlyView.
Stimuli‐activable single‐atom nanozymes (SANs) are reviewed from materials design to biomedical applications. We explain electronic‐structure tuning principles and synthesis strategies that maximize the responsiveness of metal active sites and supports to light, ultrasound, and magnetic fields.
Hyun Ko, Jungsue Choi, Hyeonjeong Noh, Sohyeon Seo, Heedong Kwon, Seungjune Lee, Hyoyoung Lee   +6 more
wiley   +1 more source

Microneedles for the treatment of migraine and orofacial pain: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Background Migraine is a common neurological disorder and a primary headache condition. Despite its central origin, migraine pain may be referred to the orofacial region via trigeminal pathways, resulting in phenotypic overlap with other orofacial pain (OFP) conditions.
Baicheng Cao, Qiuyi Chen, Yuhan Liu, Ruozhou Wu, Bin Li, Qing Cai, Lu Liu   +6 more
wiley   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source