Results 61 to 70 of about 2,610 (179)

H2O2-Generating Advanced Nanomaterials for Cancer Treatment [PDF]

Tumor cells exploit abnormal redox homeostasis and the pro-tumorigenic effect of reactive oxygen species (ROS) to enhance their survival and progression.
Abbaszadeh, Samin, Dua, Kamal, Marais, Kik, Musaie, Kiyan, Nosrati-Siahmazgi, Vahideh, Rezaei, Saman, Santos, Hélder A., Shahbazi, Mohammad-Ali, Xiao, Bo   +8 more
core   +3 more sources

Theranostic nanoplatform for high‐performance dual‐modal magnetic resonance imaging‐guided therapy of orthotopic hepatocellular carcinoma

BMEMat, EarlyView.
This article introduces a biomimetic Mn‐doped polydopamine nanoplatform (HAMM NPs) coated with cancer cell membranes. It enables targeted hepatocellular carcinoma theranostics via T1/T2 dual‐mode magnetic resonance imaging and tumor microenvironment‐triggered sonodynamic therapy/chemodynamic therapy, achieving potent antitumor efficacy in subcutaneous ...
Jiayin Lin, Wenbo Chen, Xiuqi Hou, Kai Wang, Fan Liu, Ruling Zhang, Zhong Cao, Jian Zheng   +7 more
wiley   +1 more source

Prussian blue analog with separated active sites to catalyze water driven enhanced catalytic treatments

Nature Communications, 2023
Chemodynamic therapy (CDT) uses the Fenton or Fenton-like reaction to yield toxic ‧OH following H2O2 → ‧OH for tumoral therapy. Unfortunately, H2O2 is often taken from the limited endogenous supply of H2O2 in cancer cells. A water oxidation CoFe Prussian
Liu-Chun Wang, Pei-Yu Chiou, Ya-Ping Hsu, Chin-Lai Lee, Chih-Hsuan Hung, Yi-Hsuan Wu, Wen-Jyun Wang, Gia-Ling Hsieh, Ying-Chi Chen, Li-Chan Chang, Wen-Pin Su, Divinah Manoharan, Min-Chiao Liao, Suresh Thangudu, Wei-Peng Li, Chia-Hao Su, Hong-Kang Tian, Chen-Sheng Yeh   +17 more
doaj   +1 more source

Intelligent gold nanocluster for effective treatment of malignant tumor via tumor-specific photothermal-chemodynamic therapy with AIE guidance. [PDF]

Precise and efficient therapy of malignant tumors is always a challenge. Herein, gold nanoclusters co-modified by aggregation-induced-emission (AIE) molecules, copper ion chelator (acylthiourea) and tumor-targeting agent (folic acid) were fabricated to ...
Chang, Xiaowei, Chen, Li, Chen, Xin, Cheng, Cheng, Liu, Feng, Liu, Haihu, Peng, Xiuhong, Yang, Tianfeng, Zhang, Yanmin   +8 more
core   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source

Norcantharidin/Cu2+ dual-depleting GSH nanocatalyst with pH-responsive for CT/CDT synergistic cancer therapy

Materials Today Bio
The high level of glutathione (GSH) in tumor cells can consume reactive oxygen species (ROS), seriously affecting the efficacy of chemodynamic therapy (CDT).
Xiaohuan Guo, Bingbing Cai, Qi Fang, Yanyan Chen, Yuzhu Zhou, Zhixing Liang, Changchun Wen, Yan-Cheng Liu, Hong Liang   +8 more
doaj   +1 more source

Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment

Journal of Nanobiotechnology, 2022
Chemodynamic therapy (CDT) based on Fenton or Fenton-like reactions is an emerging cancer treatment that can both effectively fight cancer and reduce side effects on normal cells and tissues, and it has made important progress in cancer treatment.
Yandong Wang, Fucheng Gao, Xiaofeng Li, Guiming Niu, Yufei Yang, Hui Li, Yanyan Jiang   +6 more
doaj   +1 more source

Fenton metal nanomedicines for imaging-guided combinatorial chemodynamic therapy against cancer

Asian Journal of Pharmaceutical Sciences, 2022
Chemodynamic therapy (CDT) is considered as a promising modality for selective cancer therapy, which is realized via Fenton reaction-mediated decomposition of endogenous H2O2 to produce toxic hydroxyl radical (•OH) for tumor ablation.
Peng Liu, Ying Peng, Jinsong Ding, Wenhu Zhou   +3 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Tumor microenvironment-responsive BSA nanocarriers for combined chemo/chemodynamic cancer therapy

Journal of Nanobiotechnology, 2022
Tumor microenvironment (TME), characterized by high glutathione (GSH), high hydrogen peroxide (H2O2) and acidic pH levels, is favorable for the growth, invasion and metastasis of cancer cells.
Ruiyi Zhang, Teng Liu, Wanzhen Li, Zhiyuan Ma, Pei Pei, Weiwei Zhang, Kai Yang, Yugui Tao   +7 more
doaj   +1 more source